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首页> 外文期刊>Critical care : >Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality
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Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality

机译：重症患者的血清脂肪细胞脂肪酸结合蛋白水平与胰岛素抵抗相关，并可预测死亡率

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IntroductionHyperglycemia and insulin resistance are commonplace in critical illness, especially in patients with sepsis. Recently, several hormones secreted by adipose tissue have been determined to be involved in overall insulin sensitivity in metabolic syndrome-related conditions, including adipocyte fatty-acid binding protein (A-FABP). However, little is known about their roles in critical illness. On the other hand, there is evidence that several adipose tissue gene expressions change in critically ill patients.MethodsA total of 120 patients (72 with sepsis, 48 without sepsis) were studied prospectively on admission to a medical ICU and compared with 45 healthy volunteers as controls. Various laboratory parameters and metabolic and inflammatory profiles were assessed within 48 hours after admission. Clinical data were collected from medical records.ResultsCompared with healthy controls, serum A-FABP concentrations were higher in all critically ill patients, and there was a trend of higher A-FABP in patients with sepsis. In multivariate correlation analysis in all critically ill patients, the serum A-FABP concentrations were independently related to serum creatinine, fasting plasma glucose, total cholesterol, TNF-alpha, albumin, and the Acute Physiology and Chronic Health Evaluation II scores. In survival analysis, higher A-FABP levels (> 40 ng/ml) were associated with an unfavorable overall survival outcome, especially in sepsis patients.ConclusionsCritically ill patients have higher serum A-FABP concentrations. Moreover, A-FABP may potentially serve as a prognostic biomarker in critically ill patients with sepsis.
机译：简介高血糖和胰岛素抵抗在重症患者中很常见，特别是在败血症患者中。最近，已经确定了脂肪组织分泌的几种激素在代谢综合征相关疾病中参与了总体胰岛素敏感性，包括脂肪细胞脂肪酸结合蛋白（A-FABP）。然而，关于它们在重大疾病中的作用知之甚少。另一方面，有证据表明危重患者有几种脂肪组织基因表达发生变化。方法前瞻性研究入院ICU的120例患者（72例败血症，48例无败血症），并与45名健康志愿者进行比较。控制。入院后48小时内评估各种实验室参数以及代谢和炎性特征。从病历中收集临床数据。结果与健康对照相比，所有危重患者血清A-FABP浓度均较高，败血症患者有升高A-FABP的趋势。在所有危重病患者的多变量相关性分析中，血清A-FABP浓度与血清肌酐，空腹血糖，总胆固醇，TNF-α，白蛋白以及急性生理和慢性健康评估II评分独立相关。在生存分析中，较高的A-FABP水平（> 40 ng / ml）与总体生存结果不良相关，尤其是在败血症患者中。结论重症患者的血清A-FABP浓度较高。此外，A-FABP可能在重症脓毒症患者中作为预后生物标志物。

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