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首页> 外文期刊>Critical care : >Comparison of cold crystalloid and colloid infusions for induction of therapeutic hypothermia in a porcine model of cardiac arrest
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Comparison of cold crystalloid and colloid infusions for induction of therapeutic hypothermia in a porcine model of cardiac arrest

机译：在心脏骤停的猪模型中冷晶状体和胶体输液诱导治疗性低温的比较

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IntroductionLarge-volume cold intravenous infusion of crystalloids has been used for induction of therapeutic hypothermia after cardiac arrest. However, the effectiveness of cold colloids has not been evaluated. Therefore, we performed an experimental study to investigate the cooling effect of cold normal saline compared to colloid solution in a porcine model of ventricular fibrillation.MethodsVentricular fibrillation was induced for 15 minutes in 22 anesthetized domestic pigs. After spontaneous circulation was restored, the animals were randomized to receive either 45 ml/kg of 1°C cold normal saline (Group A, 9 animals); or 45 ml/kg of 1°C cold colloid solution (Voluven?, 6% hydroxyethyl starch 130/0.4 in 0.9% NaCl) during 20 minutes (Group B, 9 animals); or to undergo no cooling intervention (Group C, 4 animals). Then, the animals were observed for 90 minutes. Cerebral, rectal, intramuscular, pulmonary artery, and subcutaneous fat body temperatures (BT) were recorded. In the mechanical ex-vivo sub study we added a same amount of cold normal saline or colloid into the bath of normal saline and calculated the area under the curve (AUC) for induced temperature changes.ResultsAnimals treated with cold fluids achieved a significant decrease of BT at all measurement sites, whereas there was a consistent significant spontaneous increase in group C. At the time of completion of infusion, greater decrease in pulmonary artery BT and cerebral BT in group A compared to group B was detected (?2.1?±?0.3 vs. -1.6?±?0.2°C, and ?1.7?±?0.4 vs. -1.1?±?0.3°C, p?
机译：简介大剂量的晶体冷静脉注射液已用于诱发心脏骤停后治疗性体温过低。但是，尚未评估冷胶体的有效性。因此，我们进行了一项实验研究，以研究在猪心室纤颤模型中冷生理盐水与胶体溶液相比的降温作用。方法在22头麻醉的家猪中诱发心室纤颤15分钟。恢复自发循环后，将动物随机接受45 ml / kg的1°C冷生理盐水（A组，9只动物）。或在20分钟内用45 ml / kg的1°C冷胶体溶液（Voluven？，6％羟乙基淀粉130 / 0.4在0.9％NaCl中的溶液）处理（B组，9只动物）;或不进行降温干预（C组，四只动物）。然后，观察动物90分钟。记录脑，直肠，肌内，肺动脉和皮下脂肪体温（BT）。在体外的机械子研究中，我们向生理盐水浴中添加了相同量的冷生理盐水或胶体，并计算了引起温度变化的曲线下面积（AUC）。在所有测量部位的BT，而C组的自发性持续显着增加。在完成输液时，与B组相比，A组的肺动脉BT和脑BT下降更大。相对于-1.6±±0.2℃为0.3°C，相对于-1.1±±0.3°C为±1.7°±0.4°，p ＜＜ 0.05。对脑BT减少的AUC分析显示，与B组相比，A组的降温作用更为强烈（？91？±？22 vs. -68？±？23°C / min，p？=？0.046）。在机械子研究中，对冷却液引起的温度下降的AUC分析表明，加入生理盐水比胶体溶液导致更强烈的冷却（？7155？±？647与-5733？±？636°C / min， p？=？0.008）。结论在这种心跳骤停的猪模型中，静脉注射冷生理盐水导致的脑和肺动脉BT的减少比胶体输注更为强烈。该差异至少部分地与冷却剂的各种比热容有关。

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