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Structural changes associated with poliovirus inactivation in soil.

机译:与脊髓灰质炎病毒灭活相关的结构变化。

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The loss of infectivity of poliovirus in moist and dried soils was a result of irreversible damage to the virus particles. The damage included (i) dissociation of viral genomes and capsids and (ii) degradation of viral ribonucleic acid (RNA) in the soil environment. Under drying conditions, capsid components could not be recovered from the soils. Further studies in sterile soils indicated that, under moist conditions, the viral RNA was probably damaged before dissociation from the capsid. However, in sterile, dried soil, RNA genomes were recovered largely intact from the soil. These results suggest that polioviruses are inactivated by different mechanisms in moist and drying soils.
机译:在潮湿和干燥的土壤中脊髓灰质炎病毒的传染性丧失是对病毒颗粒不可逆转破坏的结果。损害包括(i)在土壤环境中病毒基因组和衣壳的解离和(ii)病毒核糖核酸(RNA)的降解。在干燥条件下,衣壳成分不能从土壤中回收。在无菌土壤中的进一步研究表明,在潮湿条件下,病毒RNA可能在从衣壳中解离之前被破坏。然而,在无菌,干燥的土壤中,RNA基因组基本上是从土壤中完整恢复的。这些结果表明,脊髓灰质炎病毒在潮湿和干燥的土壤中通过不同的机制被灭活。

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