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首页> 外文期刊>Applied and Environmental Microbiology >Identification of a New P335 Subgroup through Molecular Analysis of Lactococcal Phages Q33 and BM13
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Identification of a New P335 Subgroup through Molecular Analysis of Lactococcal Phages Q33 and BM13

机译：通过乳球菌噬菌体Q33和BM13的分子分析鉴定一个新的P335亚组

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摘要

Lactococcal dairy starter strains are under constant threat from phages in dairy fermentation facilities, especially by members of the so-called 936, P335, and c2 species. Among these three phage groups, members of the P335 species are the most genetically diverse. Here, we present the complete genome sequences of two P335-type phages, Q33 and BM13, isolated in North America and representing a novel lineage within this phage group. The Q33 and BM13 genomes exhibit homology, not only to P335-type, but also to elements of the 936-type phage sequences. The two phage genomes also have close relatedness to phages infecting Enterococcus and Clostridium, a heretofore unknown feature among lactococcal P335 phages. The Q33 and BM13 genomes are organized in functionally related clusters with genes encoding functions such as DNA replication and packaging, morphogenesis, and host cell lysis. Electron micrographic analysis of the two phages highlights the presence of a baseplate more reminiscent of the baseplate of 936 phages than that of the majority of members of the P335 group, with the exception of r1t and LC3.
机译：乳球菌乳品发酵菌株一直受到乳品发酵设施中噬菌体的不断威胁，特别是所谓的936，P335和c2物种的成员。在这三个噬菌体组中，P335物种的成员遗传多样性最强。在这里，我们介绍了在北美分离的两个P335型噬菌体Q33和BM13的完整基因组序列，代表了该噬菌体组中的新谱系。 Q33和BM13基因组显示出同源性，不仅与P335型同源，而且与936型噬菌体序列的同源性。这两个噬菌体基因组还与感染肠球菌和 Clostridium 的噬菌体密切相关，这是乳球菌P335噬菌体中迄今未知的特征。 Q33和BM13基因组被组织在功能相关的簇中，簇中的基因编码诸如DNA复制和包装，形态发生和宿主细胞裂解等功能。对两个噬菌体的电子显微分析表明，除了r1t和LC3外，与P335组大多数成员相比，存在一个比936个噬菌体更让人联想到的底板。

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