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Effects of Antimicrobial Agents on the Milky Disease Bacteria Bacillus popilliae and Bacillus lentimorbus

机译：抗菌剂对乳腺疾病杆菌，芽孢杆菌和慢芽孢杆菌的影响

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摘要

The effects of antibiotics, sulfonamides, and other antimicrobial agents on vegetative cultures of five strains of milky disease bacteria were compared with those on Bacillus subtilis Cohn emend. Prazmowski, Staphylococcus aureus Rosenbach, Sarcina lutea Schroeter, Escherichia coli (Migula) Castellani and Chalmers, Saccharomyces pastorianus Hansen, and Mucor ramannianus Moel. Similar numbers of viable cells of each organism were exposed to the test materials by use of an antibiotic-sensitivity disc method adapted from techniques recommended by the Food and Drug Administration in the Federal Register. The results suggest that vancomycin or ristocetin, as well as a few other materials, might be useful in controlling contamination either during culture of the fastidious milky disease bacteria or in large populations of vegetative cells undergoing treatment to induce sporulation. Inhibitory concentrations of vancomycin and ristocetin in shaken-tube tests were much lower than expected in comparison with results of sensitivity-disc tests on the milky disease bacteria. Sublethal concentrations of the two antibiotics elicited some morphological change in the bacteria.
机译：比较了抗生素，磺胺类药物和其他抗微生物剂对5株乳状细菌细菌营养培养的影响以及对枯草芽孢杆菌Cohn emend的影响。 Prazmowski，金黄色葡萄球菌Rosenbach，Sarcina lutea Schroeter，大肠杆菌（Migula）Castellani and Chalmers，巴斯德酵母菌Hansen和Mucor ramannianus Moel。通过使用抗生素敏感性光盘方法，使每种生物体具有相似数量的活细胞暴露于测试材料，该方法改编自美国联邦食品药品监督管理局的食品和药物管理局推荐的技术。结果表明，万古霉素或瑞斯托霉素以及其他一些材料可能在控制乳质病细菌培养过程中或在接受诱导处理孢子的大量营养细胞中控制污染。与乳状病菌的敏感性盘试验结果相比，摇管试验中万古霉素和瑞斯托菌素的抑制浓度远低于预期。亚致死浓度的两种抗生素引起细菌的某些形态变化。

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