• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied Microbiology >Role of the Kidney in Staphylococcal Enterotoxemia
【24h】

Role of the Kidney in Staphylococcal Enterotoxemia

机译：肾脏在葡萄球菌肠毒素血症中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Highly purified staphylococcal enterotoxin B (SEB) is known to accumulate rapidly within the kidneys of experimental animals. The present study was performed to determine whether the predominant renal localization of SEB was of fundamental pathophysiologic importance in the development of lethal shock after the intravenous administration of this toxin to monkeys. Eight bilaterally nephrectomized Macaca mulatta given 10 μg of SEB per kg survived for an average time period less than half that of nephrectomized control animals (P < 0.001). Their survival time, however, was similar to that of control, sham-nephrectomized monkeys given an equal amount of SEB. Thus, no evidence was obtained to suggest that the kidney converted purified SEB to a more potent toxin. The glomerular filtration and proximal tubule cell accumulation of SEB possibly occurred as a nonspecific consequence of its molecular size, and such localization within the kidney might have served to reduce the quantity of SEB reaching some other site of toxic activity. Similar pathological and clinical findings were demonstrated in monkeys from both experimental and control groups; these could not be ascribed to SEB alone.
机译：已知高度纯化的葡萄球菌肠毒素B（SEB）在实验动物的肾脏内迅速积累。进行本研究是为了确定SEB的主要肾脏定位在向猴子静脉内注射这种毒素后是否对致命性休克的发展具有根本的病理生理意义。八只双边肾切除的猕猴给予每公斤SEB 10μg，平均存活时间不到肾切除的对照动物的一半（P <0.001）。然而，它们的存活时间与给予相同SEB量的伪造肾切除的对照猴子相似。因此，没有证据表明肾脏将纯化的SEB转化为更有效的毒素。 SEB的肾小球滤过和近端小管细胞积聚可能是其分子大小的非特异性结果，肾脏中的这种定位可能有助于减少SEB到达其他有毒活性部位的数量。实验组和对照组的猴子都表现出相似的病理和临床发现。这些不能仅归因于SEB。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号