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首页> 外文期刊>Applied Microbiology >Tobramycin (Nebramycin Factor 6): In Vitro Activity Against Pseudomonas aeruginosa
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Tobramycin (Nebramycin Factor 6): In Vitro Activity Against Pseudomonas aeruginosa

机译：妥布霉素（Nebramycin因子6）：对抗铜绿假单胞菌的体外活性

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Tobramycin (factor 6 of the nebramycin complex) is a new aminoglycoside antibiotic isolated from Streptomyces tenebrarius which is active against S. aureus, Enterobacteriaceae, and Pseudomonas aeruginosa. Susceptibility to tobramycin of 96 strains of P. aeruginosa, including 45 recent isolates from blood, was studied by using agar and broth dilution methods. The minimum inhibitory concentration (MIC) for 83 of 96 strains was 3.12 μg/ml or lower in Mueller Hinton agar; MIC values were two to eight times lower in Mueller Hinton broth tests. Agar dilution MIC values were generally lower than those obtained in parallel tests with gentamicin. Killing curves obtained from serial sampling of broth cultures showed a 100- to 10,000-fold decline in viability of log-phase organisms within 30 min of exposure to the drug. Two-dimensional agar dilution tests with carbenicillin and tobramycin with 79 strains showed additive or synergistic effects; no antagonism was documented. Seventy-eight of 79 strains were inhibited by a combination of 50 μg of carbenicillin per ml and 1.56 μg of tobramycin per ml, blood levels which seem attainable in man. Tobramycin appears to be a potent, rapidly bactericidal antibiotic against P. aeruginosa and merits clinical evaluation.
机译：妥布霉素（Nebramycin复合物的6因子）是一种新的氨基糖苷类抗生素，从黄链霉菌中分离出来，对金黄色葡萄球菌，肠杆菌科和铜绿假单胞菌具有活性。使用琼脂和肉汤稀释法研究了96株铜绿假单胞菌对妥布霉素的敏感性，包括最近从血液中分离的45株。在Mueller Hinton琼脂中，对96个菌株中的83个的最小抑菌浓度（MIC）为3.12μg/ ml或更低;在Mueller Hinton肉汤测试中，MIC值降低了2至8倍。琼脂稀释MIC值通常低于庆大霉素平行试验中获得的MIC值。从肉汤培养液的连续采样获得的杀灭曲线显示，暴露于药物的30分钟内，对数期生物的生存能力下降了100到10,000倍。用羧苄青霉素和妥布霉素对79个菌株进行二维琼脂稀释试验显示出加和或协同作用。没有敌对的记录。每毫升50微克羧苄青霉素和每毫升1.56微克妥布霉素的结合抑制了79株菌株中的78种，这在人看来是可以达到的。妥布霉素似乎是一种有效的，对铜绿假单胞菌快速杀菌的抗生素，值得临床评估。

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