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Hemodialysis Properties of Clindamycin (7-Chloro-7-Deoxylincomycin)

机译:克林霉素(7-氯-7-脱氧林可霉素)的血液透析特性

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The effect of hemodialysis (Kolff-type machine) on clindamycin blood levels in anuric patients was studied. At 1 hr after oral ingestion of drug, blood levels ranged from 1.23 to 5.17 μg/ml and fell thereafter. Half-times for peripheral removal were 3.36 μg/ml ± 0.22 when subjects were “off” dialysis and 3.14 μg/ml ± 0.09 during dialysis. Their difference was not statistically significant, indicating that hemodialysis does not affect the blood level of clindamycin. In all studies, significant levels of the antibiotic were present at 12 hr.
机译:研究了血液透析(Kolff型机器)对无尿患者克林霉素血药浓度的影响。口服药物后1小时,血液水平为1.23至5.17μg/ ml,此后下降。当受试者“不进行”透析时,周边去除的半时间为3.36μg/ ml±0.22,而在透析期间为3.14μg/ ml±0.09。它们之间的差异无统计学意义,表明血液透析不会影响克林霉素的血药浓度。在所有研究中,在12小时内均存在大量抗生素。

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