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首页> 外文期刊>Applied Microbiology >Production of Nucleic Acid-Related Substances by Fermentative Processes. XXVIII. Accumulation of 5′ Inosinic Acid by a Manganese-Insensitive Mutant of Brevibacterium ammoniagenes
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Production of Nucleic Acid-Related Substances by Fermentative Processes. XXVIII. Accumulation of 5′ Inosinic Acid by a Manganese-Insensitive Mutant of Brevibacterium ammoniagenes

机译：通过发酵过程生产核酸相关物质。二十八。锰致病性短杆菌细菌突变体对5'肌苷的积累

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摘要

A manganese-insensitive mutant, KY 13105, of Brevibacterium ammoniagenes which accumulates considerable amounts of 5′ inosinic acid (IMP) in the presence of 100 to 1,000 μg of Mn2+ per liter was obtained from an IMP-producing mutant of a manganese-sensitive strain, KY 13102. The effects of Mn2+ at 0 to 30 μg/liter on IMP accumulation by KY 13105 were similar to those by KY 13102. However, the accumulation of IMP by KY 13105 was not affected by 100 to 1,000 μg of Mn2+ per liter, showing a clear difference from KY 13102. The accumulation of IMP by KY 13105 was always accompanied by cellular morphological changes irrespective of Mn2+ concentration. In the presence of Mn2+, factors which affect IMP accumulation by KY 13105 were examined. Most of the nutrients tested stimulated IMP accumulation at a relatively low concentration (2 g/liter). Iron, calcium, and zinc were found to be essential for IMP accumulation and were independent of Mn2+. Biotin regulated the growth but not the accumulation of IMP. Under limited or surplus amounts of Mn2+, the dynamics of IMP fermentation were followed. Under both conditions, the fermentations proceeded in a similar way. The morphological changes were found to be closely related to IMP accumulation.
机译：从产生IMP的锰敏感菌株中获得了一种不敏感的氨气短杆菌细菌突变体KY 13105，该突变体在每升存在100至1,000μgMn2 +的情况下积累了大量的5'肌苷酸（IMP）。 ，KY13102。Mn2 +在0到30μg/ l时对KY 13105的IMP积累的影响与KY 13102相似。但是，KY 13105的IMP积累不受每升100至1,000μgMn2 +的影响。 ，显示出与KY 13102明显不同。KY13105积累的IMP总是伴随着细胞形态的变化，而与Mn2 +的浓度无关。在存在Mn2 +的情况下，检查了影响KY 13105的IMP积累的因素。测试的大多数营养素以相对较低的浓度（2克/升）刺激了IMP的积累。发现铁，钙和锌对于IMP积累至关重要，并且与Mn2 +无关。生物素调节IMP的生长，但不调节IMP的积累。在有限或过量的Mn2 +下，跟踪IMP发酵的动力学过程。在两种条件下，发酵都以相似的方式进行。发现形态变化与IMP积累密切相关。

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