Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System

Thomas Hartmann; Michaela Dümig; Basem M. Jaber; Edyta Szewczyk; Patrick Olbermann; Joachim Morschh?user; Sven Krappmann

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Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System

机译：通过使用β-Rec/六个位点特异性重组系统，在人类病原体烟曲霉中检测自消灭标记

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Recyclable markers based on site-specific recombination allow repetitive gene targeting in filamentous fungi. Here we describe for the first time functionality of the bacterial recombination system employing β serine recombinase acting on six recognition sequences (β-rec/ six ) in a fungal host, the human pathogen Aspergillus fumigatus , and its use in establishing a self-excising resistance marker cassette for serial gene replacement.

机译：基于位点特异性重组的可回收标记物可在丝状真菌中进行重复的基因靶向。在这里，我们首次描述了使用β丝氨酸重组酶作用于真菌宿主（人病原体烟曲霉）中的六个识别序列（β-rec/ 6）的细菌重组系统的功能及其在建立自消灭抗性中的用途用于序列基因替换的标记盒。

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《Applied Microbiology》 |2010年第18期|共5页
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Thomas Hartmann; Michaela Dümig; Basem M. Jaber; Edyta Szewczyk; Patrick Olbermann; Joachim Morschh?user; Sven Krappmann;
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1. Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System [J] . Thomas Hartmann, Michaela Dümig, Basem M. Jaber, Applied Microbiology . 2010,第18期

机译：通过使用β-Rec/六个位点特异性重组系统，在人类病原体烟曲霉中检测自消灭标记
2. Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System [J] . Thomas Hartmann, Michaela Dümig, Basem M. Jaber, Applied and Environmental Microbiology . 2010,第18期

机译：通过使用β-Rec/六个位点特异性重组系统，在人类病原体烟曲霉中检测自消灭标记
3. Evidence for genetic differentiation and variable recombination rates among Dutch populations of the opportunistic human pathogen Aspergillus fumigatus [J] . Klaassen C.H.W., Gibbons J.G., Fedorova N.D., Molecular ecology . 2012,第1期

机译：机会性人类病原体烟曲霉荷兰种群中遗传分化和可变重组率的证据
4. SIMULTANEOUS DUAL PROTEOME ANALYSIS TOWARDS UNDERSTANDING NEUTROPHIL INTERACTION WITH THE HUMAN-PATHOGENIC FUNGUS ASPERGILLUS FUMIGATUS [C] . Thomas Kruger, Iordana A. Shopova, Tobias Muller, International Mass Spectrometry Conference . 2018

机译：与人致病性真菌曲霉富泻的嗜嗜中性粒细胞相互作用的同时蛋白质组织分析
5. Trehalose-6-phosphate is required for metabolism and virulence in the human fungal pathogen Aspergillus fumigatus [D] . Puttikamonkul, Srisombat 2012

机译：海藻糖6-磷酸是人类真菌病原体烟曲霉中新陈代谢和毒力所必需的
6. Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System [O] . Thomas Hartmann, Michaela Dümig, Basem M. Jaber, 2010

机译：通过使用β-Rec/六个位点特异性重组系统在人类病原体烟曲霉中检测自消灭标记
7. Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System ▿ [O] . Hartmann, Thomas, Dümig, Michaela, Jaber, Basem M., 2010

机译：通过使用β-Rec/六个位点特异性重组系统验证人病原菌烟曲霉中自消灭标记的能力▿

Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System

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