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Frequency of R Factor-mediated Multiple Drug Resistance in Klebsiella and Aerobacter

机译：R因子介导的克雷伯菌和气杆菌多重耐药的频率

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A comparative study was done on the transfer frequency of R factors from 90 strains of multiple drug-resistant Aerobacter and 81 strains of Klebsiella to Escherichia coli CSH-2 (F-, met-, pro-, Nal-r). The most common resistance patterns for the Aerobacter isolants were ampicillin streptomycin chloramphenicol tetracycline and ampicillin streptomycin chloramphenicol tetracycline kanamycin neomycin; for the Klebsiella isolants, the most common resistance pattern was ampicillin kanamycin streptomycin tetracycline chloramphenicol neomycin. R factors were isolated from 14.1% of the Aerobacter strains; 61.5% of these R factors harbored R determinants for ampicillin streptomycin tetracycline. R factors were isolated from 79.1% of the Klebsiella strains; four R factors were isolated with significant frequency; streptomycin chloramphenicol kanamycin neomycin, 37.5%; ampicillin streptomycin tetracycline kanamycin neomycin, 14.1%; ampicillin streptomycin tetracycline, 12.5%; and streptomycin chloramphenicol tetracycline, 12.5%. Chloramphenicol, kanamycin, and neomycin resistance was rarely transferred from the Aerobacter strains, although over 50% of the clinical isolants possessed resistance to these antibiotics. In contrast, over 75% of the Klebsiella strains transferred resistance to chloramphenicol, kanamycin, neomycin. Highest frequency of transferred resistance to individual drugs in the Aerobacter strains was to streptomycin (14.8%), whereas in the Klebsiella group resistance to four drugs was transferred at a very high frequency: streptomycin (80.8%), chloramphenicol (78.5%), kanamycin (76.4%), and neomycin (75.9%).
机译：比较了R因子从90株多重耐药的Aeroero细菌和81克雷伯氏菌到大肠杆菌CSH-2（F-，met-，pro-，Nal-r）的转移因子的转移频率。对Aerobacter分离物最常见的耐药模式是氨苄青霉素链霉素氯霉素四环素和氨苄青霉素链霉素氯霉素四环素卡那霉素新霉素。对于克雷伯菌隔离剂，最常见的耐药模式是氨苄青霉素卡那霉素链霉素四环素氯霉素新霉素。 R因子是从14.1％的Aerobacter菌株中分离出来的;这些R因子中有61.5％包含氨苄青霉素链霉素四环素的R决定因素。从79.1％的克雷伯菌中分离出R因子;四个R因子的分离频率很高。链霉素氯霉素卡那霉素新霉素，37.5％;氨苄青霉素链霉素四环素卡那霉素新霉素，14.1％。氨苄青霉素链霉素四环素，12.5％;和链霉素氯霉素四环素，为12.5％。尽管超过50％的临床隔离剂对这些抗生素具有耐药性，但氯霉素，卡那霉素和新霉素的耐药性很少从气杆菌菌株转移过来。相比之下，超过75％的克雷伯菌菌株转移了对氯霉素，卡那霉素，新霉素的抗性。在Aerobacter菌株中，对个别药物的抗药性转移的最高频率是对链霉素的抗药性（14.8％），而在克雷伯菌组中，对四种药物的抗药性的转移频率很高：链霉素（80.8％），氯霉素（78.5％） ），卡那霉素（76.4％）和新霉素（75.9％）。

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