Bioassay for Hamycin and Amphotericin B in Serum and Other Biological Fluids

Smith Shadomy; Judith A. McCay; Stephen I. Schwartz

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Bioassay for Hamycin and Amphotericin B in Serum and Other Biological Fluids

机译：血清和其他生物液中的Hamycin和Amphotericin B的生物测定

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A bioassay suitable for measuring concentrations of the polyene antifungal agents hamycin and amphotericin B in biological fluids is described. By using Paecilomyces varioti as the indicator organism, sensitivity of the bioassay was found to be in the range of 0.01 to 0.02 μg/ml. A linear dose-response curve was obtained with amphotericin B; the curve for hamycin was curvilinear. In a series of assays, hamycin serum levels in the range of 0.01 to 3.5 μg/ml were measured; with amphotericin B, serum levels in the range of 0.015 to 0.175 μg/ml were measured in patients receiving orthodox intravenous medication and as high as 9.0 μg/ml in one patient treated with extraordinarily high doses of the drug.

机译：描述了适合于测量生物流体中多烯抗真菌剂hamycin和两性霉素B浓度的生物测定法。通过使用天花拟青霉作为指示生物，该生物测定的灵敏度在0.01至0.02μg/ ml的范围内。用两性霉素B获得线性剂量-反应曲线。哈米霉素的曲线是曲线的。在一系列测定中，测出的hamycin血清水平在0.01至3.5μg/ ml的范围内。在使用两性霉素B的情况下，在接受正统静脉注射药物的患者中测得的血清水平在0.015至0.175μg/ ml范围内，在接受过高剂量药物治疗的一名患者中测得的血清水平高达9.0μg/ ml。

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《Applied Microbiology》 |1969年第4期|共7页
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Smith Shadomy; Judith A. McCay; Stephen I. Schwartz;
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Bioassay for Hamycin and Amphotericin B in Serum and Other Biological Fluids

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