Several antibiotics reduced growth of bacteria without killing them when present in the range of concentrations of significance in assaying. The reduction in growth rate was linearly related to concentration of antibiotic. From this fact may be derived an equation of the form log N = A - BC where N is the concentration of bacteria at the end of the incubation period, C is the concentration of antibiotic, and A and B are constants. This equation is used to guide the selection of the best range of concentrations of unknown for assay and to show the large influence of variations of temperature upon an assay.
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机译：当存在于测定中的重要浓度范围内时，几种抗生素可减少细菌的生长，而不会杀死细菌。生长速率的降低与抗生素浓度呈线性关系。从这一事实可以得出log N = A-BC形式的方程，其中N是温育期结束时细菌的浓度，C是抗生素的浓度，A和B是常数。该方程式可指导选择未知浓度的最佳浓度范围进行测定，并显示温度变化对测定的巨大影响。
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