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首页> 外文期刊>Applied Microbiology >Serum Antibacterial Activity After Oral Suspensions and Capsules of Triacetyloleandomycin and Erythromycin Estolate
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Serum Antibacterial Activity After Oral Suspensions and Capsules of Triacetyloleandomycin and Erythromycin Estolate

机译：口服三乙酰油霉素和红霉素硬脂酸酯的悬浮液和胶囊后的血清抗菌活性

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摘要

Comparison of serum antibacterial activity against a beta-hemolytic streptococcus and a penicillin-resistant staphylococcus was made in a cross-over study in volunteers after ingestion of oral suspensions and capsules of triacetyloleandomycin and erythromycin estolate. Oral suspensions yielded earlier peak titers, but ultimate peak titers and duration of activity were similar to those observed after ingestion of capsules. Antibacterial activity of serum against both organisms was consistently greater with both erythromycin estolate preparations than with the triacetyloleandomycin preparations. These in vitro data were comparable to observations made previously in monkeys infected with the same organisms, although comparative clinical efficacy in monkeys did not reflect these implied therapeutic differences.
机译：在一项交叉研究中，通过摄取口服口服三乙酰油霉素和三乙四烯多柔霉素和乙二酸酯的胶囊和胶囊，对志愿者的血清抗β-溶血性链球菌和抗青霉素的葡萄球菌进行了比较。口服悬浮液产生较早的峰值滴度，但最终的峰值滴度和活性持续时间与摄入胶囊后观察到的相似。两种依托红霉素制剂的血清对两种生物的抗菌活性始终比三乙酰基柔顺霉素制剂高。这些体外数据与以前在感染相同生物的猴子中所做的观察结果相当，尽管在猴子中比较的临床疗效并未反映出这些暗示的治疗差异。

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