A Microbiological Assay for Estimating Concentrations of Camptothecin Lactone in Mouse Tissues

Dale E. Hunt; Robert F. Pittillo

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A Microbiological Assay for Estimating Concentrations of Camptothecin Lactone in Mouse Tissues

机译：估计小鼠组织中喜树碱内酯浓度的微生物测定

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The marked sensitivity of the yeast Hansenula wingei NRRL Y-2340 strain 5 to a new antineoplastic alkaloid served as the basis for a logarithmic-ratio microbiological assay which has been developed for the estimation of concentrations of camptothecin lactone (or cytotoxic equivalents) in tissues of mice. The utility of this assay has been demonstrated by presenting data which show the concentrations of camptothecin lactone (or cytotoxic equivalents) detected in various tissues of mice at intervals following intraperitoneal injection of a 1 or 0.5 ld10 dose of this drug.

机译：酵母翅果汉逊酵母NRRL Y-2340菌株5对新型抗肿瘤生物碱的显着敏感性作为对数比微生物测定的基础，该测定已用于估计喜树碱组织中喜树碱内酯（或细胞毒性当量）的浓度。老鼠。通过提供数据来证明该测定法的实用性，该数据显示在腹膜内注射1或0.5 ld10剂量的这种药物后，在小鼠的各种组织中检测到的喜树碱内酯浓度（或细胞毒性当量）。

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《Applied Microbiology》 |1968年第6期|共4页
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Dale E. Hunt; Robert F. Pittillo;
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中图分类微生物学;
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6. A Microbiological Assay for Estimating Concentrations of Camptothecin Lactone in Mouse Tissues [O] . Dale E. Hunt, Robert F. Pittillo 1968

机译：估计小鼠组织中喜树碱内酯浓度的微生物测定
7. A Microbiological Assay for Estimating Concentrations of Camptothecin Lactone in Mouse Tissues [O] . Dale E. Hunt, Robert F. Pittillo 1968

机译：用于估算小鼠组织中的喜树碱内酯浓度的微生物测定
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机译：使用（129）I浓度在人体组织中估算辐射剂量的可行性（131）I：汉福德环境剂量重建项目。

A Microbiological Assay for Estimating Concentrations of Camptothecin Lactone in Mouse Tissues

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