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Association of Campylobacter jejuni Metabolic Traits with Multilocus Sequence Types

机译：空肠弯曲菌代谢性状与多基因座序列类型的关联

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In this study, we describe the association of three Campylobacter jejuni metabolism-related traits, γ-glutamyl-transpeptidase (GGT), fucose permease ( fucP ), and secreted l-asparaginase [ ansB (s)], with multilocus sequence types (STs). A total of 710 C. jejuni isolates with known STs were selected and originated from humans, poultry, bovines, and the environment. Among these isolates, we found 31.1% to produce GGT and 49.3% and 30.3% to be positive for ansB (s) and fucP , respectively. The combination of GGT production, the presence of ansB (s), and the absence of fucP was associated with ST-22, ST-586, and the ST-45 and ST-283 clonal complexes (CCs), which were the main STs and CCs found among the human and chicken isolates. The ST-21 CC was associated with the presence of fucP and was the major CC among the bovine isolates. Although the ST-61 CC was the second major CC among the bovine isolates, these isolates did not have any of the markers studied, making the role of fucP in bovine gut colonization questionable. The ST-45 CC was subdivided into three groups that were attributed solely to ST-45. One group showed a marker combination described previously, another group was found to be positive for ansB (s) only, and the third group did not have any of the markers studied. These results suggest that the host association of these markers seems to be indirect and may arise as a consequence of host-ST and -CC associations. Thus, a representative collection of STs should be tested to draw sensible conclusions in similar studies.
机译：在这项研究中，我们描述了空肠弯曲杆菌代谢相关性状，γ-谷氨酰转肽酶（GGT），岩藻糖通透酶（fucP）和分泌的l-天冬酰胺酶[ansB（s）]与多基因座序列类型（STs）的关联。 ）。总共选择了710株具有已知ST的空肠弯曲杆菌分离株，它们来自人类，家禽，牛和环境。在这些分离株中，我们发现分别有ansB（s）和fucP阳性的GGT占31.1％，阳性的占49.3％。 GGT的产生，ansB的存在和fucP的缺失与主要的STs ST-22，ST-586以及ST-45和ST-283克隆复合物（CC）相关联在人类和鸡分离株中发现了CCs。 ST-21 CC与fucP的存在有关，是牛分离株中的主要CC。尽管ST-61 CC是牛分离株中的第二大CC，但这些分离株没有任何已研究的标记，这使fucP在牛肠道定植中的作用令人怀疑。 ST-45 CC分为三组，仅归因于ST-45。一组显示了先前描述的标记组合，另一组仅对ansB呈阳性，而第三组没有研究任何标记。这些结果表明，这些标志物的宿主关联似乎是间接的，可能是宿主-ST和-CC关联的结果。因此，应该对代表性的ST进行测试，以在类似研究中得出明智的结论。

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