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首页> 外文期刊>Applied Microbiology >2,3-Butanediol Production by Acetogenic Bacteria, an Alternative Route to Chemical Synthesis, Using Industrial Waste Gas
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2,3-Butanediol Production by Acetogenic Bacteria, an Alternative Route to Chemical Synthesis, Using Industrial Waste Gas

机译：使用工业废气，通过产乙酸细菌生产化学合成的替代途径生产2,3-丁二醇

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2,3-Butanediol (23BD) is a high-value chemical usually produced petrochemically but which can also be synthesized by some bacteria. To date, the best microbial 23BD production rates have been observed using pathogenic bacteria in fermentation systems that depend on sugars as the carbon and energy sources for product synthesis. Here we present evidence of 23BD production by three nonpathogenic acetogenic Clostridium species— Clostridium autoethanogenum , C. ljungdahlii , and C. ragsdalei —using carbon monoxide-containing industrial waste gases or syngas as the sole source of carbon and energy. Through an analysis of the C. ljungdahlii genome, the complete pathway from carbon monoxide to 23BD has been proposed. Homologues of the genes involved in this pathway were also confirmed for the other two species investigated. A gene expression study demonstrates a correlation between mRNA accumulation from 23BD biosynthetic genes and the onset of 23BD production, while a broader expression study of Wood-Ljungdahl pathway genes provides a transcription-level view of one of the oldest existing biochemical pathways.
机译：2,3-丁二醇（23BD）是一种高价值化学品，通常通过石油化学生产，但也可以由某些细菌合成。迄今为止，已经在发酵系统中使用致病菌观察到了最佳的微生物23BD生产率，该系统依靠糖作为产品合成的碳源和能源。在这里，我们提供了使用含一氧化碳的工业废气或合成气作为碳和能源的唯一来源的三种非致病性产乙酸梭菌（Clostridium autoethanogenum，C。ljungdahlii和C. ragsdalei）生产23BD的证据。通过对C. ljungdahlii基因组的分析，已提出了从一氧化碳到23BD的完整途径。还证实了所研究的其他两个物种的参与该途径的基因的同源物。基因表达研究表明23BD生物合成基因的mRNA积累与23BD生产开始之间的相关性，而Wood-Ljungdahl途径基因的更广泛表达研究提供了最古老的现有生化途径之一的转录水平视图。

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