The Tape Measure Protein of the Staphylococcus aureus Bacteriophage vB_SauS-phiIPLA35 Has an Active Muramidase Domain

Lorena Rodríguez-Rubio; Dolores Gutiérrez; Beatriz Martínez; Ana Rodríguez; Friedrich G?tz; Pilar García

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The Tape Measure Protein of the Staphylococcus aureus Bacteriophage vB_SauS-phiIPLA35 Has an Active Muramidase Domain

机译：金黄色葡萄球菌噬菌体vB_SauS-phiIPLA35的卷尺蛋白具有活跃的Muramidase域

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Tailed double-stranded DNA (dsDNA) bacteriophages frequently harbor structural proteins displaying peptidoglycan hydrolytic activities. The tape measure protein from Staphylococcus aureus bacteriophage vB_SauS-phiIPLA35 has a lysozyme-like and a peptidase_M23 domain. This report shows that the lysozyme-like domain (TG1) has muramidase activity and exhibits in vitro lytic activity against live S. aureus cells, an activity that could eventually find use in the treatment of infections.

机译：尾部双链DNA（dsDNA）噬菌体通常带有显示肽聚糖水解活性的结构蛋白。来自金黄色葡萄球菌噬菌体vB_SauS-phiIPLA35的卷尺蛋白质具有溶菌酶样和肽酶_M23结构域。该报告表明，溶菌酶样结构域（TG1）具有muramidase活性，并表现出针对活的金黄色葡萄球菌细胞的体外裂解活性，该活性最终可用于治疗感染。

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《Applied Microbiology》 |2012年第17期|共3页
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Lorena Rodríguez-Rubio; Dolores Gutiérrez; Beatriz Martínez; Ana Rodríguez; Friedrich G?tz; Pilar García;
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6. The Tape Measure Protein of the Staphylococcus aureus Bacteriophage vB_SauS-phiIPLA35 Has an Active Muramidase Domain [O] . Lorena Rodríguez-Rubio, Dolores Gutiérrez, Beatriz Martínez, 2012

机译：金黄色葡萄球菌噬菌体卷尺vB_SauS-phiIPLA35的卷尺蛋白具有活跃的Muramidase域
7. The tape measure protein of the Staphylococcus aureus bacteriophage vB_SauS-phiIPLA35 has an active muramidase domain [O] . Rodríguez, Lorena, Gutiérrez, Diana, Martínez Fernández, Beatriz, 2012

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8. Fibronectin-Binding Proteins in Group C Streptococci and 'Staphylococcus aureus'. Identification and Characterization of the Binding Domains. [R] . Lindgren, P. E. 1992

机译：C组链球菌和“金黄色葡萄球菌”中的纤连蛋白结合蛋白。结合域的鉴定和表征。

The Tape Measure Protein of the Staphylococcus aureus Bacteriophage vB_SauS-phiIPLA35 Has an Active Muramidase Domain

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