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首页> 美国政府科技报告 >Fibronectin-Binding Proteins in Group C Streptococci and 'Staphylococcus aureus'. Identification and Characterization of the Binding Domains.
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Fibronectin-Binding Proteins in Group C Streptococci and 'Staphylococcus aureus'. Identification and Characterization of the Binding Domains.

机译：C组链球菌和“金黄色葡萄球菌”中的纤连蛋白结合蛋白。结合域的鉴定和表征。

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The genes coding for fibronectin-binding proteins from Staphylococcus aureus strain 8325-4, FnBPA (1018 amino acids), and from Streptococcus dysgalactiae strain S2, FnBA (1091 amino acids) and FnBB (1117 amino acids), have been cloned, sequenced and expressed in Escherichia coli. A gene encoding a fibronectin-binding protein from Streptococcus equisimilis strain Se165, FSE, has also been cloned and partly characterized. The fibronectin-binding domains were localized to repetitive regions in the COOH-terminal parts of the proteins. These regions consist of 32-43 amino acids per unit, repeated 2.5-3 times. On the nucleotide level, as well as on the amino acid level, no obvious homologies were found between the three genes or proteins from S. aureus and S. dysgalactiae, except for an octapeptide present in the repeats of FnBA and FnBB from S. dysgalactiae. However, the COOH-terminal part of FSE from S. equisimilis, including the repeated fibronectin-binding domain, is more than 85% homologous to the corresponding part of FnBB from S. dysgalactiae.

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