Immunogenicity of Rabies Virus Inactivated by β-Propiolactone, Acetylethyleneimine, and Ionizing Irradiation

T. J. Wiktor; H. G. Aaslestad; M. M. Kaplan

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Immunogenicity of Rabies Virus Inactivated by β-Propiolactone, Acetylethyleneimine, and Ionizing Irradiation

机译：β-丙内酯，乙酰基亚乙基亚胺和电离辐射灭活的狂犬病病毒的免疫原性

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Ionizing radiation, β-propiolactone, and acetylethyleneimine were compared for their ability as virus-inactivating agents for the preparation of rabies vaccine. Each agent reduced viral infectivity exponentially; ionizing radiation also destroyed viral hemagglutinin. The vaccine prepared by ionizing radiation was equal or superior to that prepared by β-propiolactone in its ability to protect mice from rabies infection. The acetylethyleneimine-treated vaccine was a less potent immunogen.

机译：比较了电离辐射，β-丙内酯和乙酰基亚乙基亚胺作为制备狂犬病疫苗的病毒灭活剂的能力。每种药物均以指数方式降低病毒感染性。电离辐射也破坏了病毒血凝素。通过电离辐射制备的疫苗在保护小鼠免受狂犬病感染的能力方面与通过β-丙内酯制备的疫苗相同或更高。乙酰乙撑亚胺处理的疫苗免疫力较弱。

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《Applied Microbiology》 |1972年第5期|共5页
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T. J. Wiktor; H. G. Aaslestad; M. M. Kaplan;
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1. Immunogenicity of Rabies Virus Inactivated by β-Propiolactone, Acetylethyleneimine, and Ionizing Irradiation [J] . T. J. Wiktor, H. G. Aaslestad, M. M. Kaplan Applied Microbiology . 1972,第5期

机译：β-丙内酯，乙酰基亚乙基亚胺和电离辐射灭活的狂犬病病毒的免疫原性
2. Immunogenicity and protective efficacy in mice and hamsters of a beta-propiolactone inactivated whole virus SARS-CoV vaccine. [J] . Roberts A, Lamirande EW, Vogel L, Viral immunology . 2010,第5期

机译：β-丙内酯灭活的全病毒SARS-CoV疫苗在小鼠和仓鼠中的免疫原性和保护功效。
3. Inactivated Rabies Virus-Based Ebola Vaccine Preserved by Vaporization Is Heat-Stable and Immunogenic Against Ebola and Protects Against Rabies Challenge [J] . Kurup Drishya, Fisher Christine R., Smith Todd G., The Journal of Infectious Diseases . 2019,第9期

机译：通过汽化保存的灭活狂犬病病毒的埃博拉疫苗是对埃博拉的热稳定和免疫原性，并防止狂犬病攻击
4. Immunogenicity of the ERA G 333 Rabies Virus Strain in Foxes and Raccoon Dogs [C] . D. Bankovskiy1, G. Safonov, Y. Kurilchuk Joint World Organisation for Animal Health/World Health Organization/European Union International Conference "Towards the elimination of rabies in Eurasia" . 2008

机译：ERA G 333狂犬病病毒菌株在狐狸和浣熊犬的免疫原性
5. A comprehensive analysis of interferon-beta's role in shaping the immunogenicity and pathogenicity of rabies virus: Development of a novel vaccine vector. [D] . Faul, Elizabeth J. 2010

机译：干扰素-β在塑造狂犬病病毒的免疫原性和致病性中的作用的全面分析：新型疫苗载体的开发。
6. Immunogenicity of Rabies Virus Inactivated by β-Propiolactone Acetylethyleneimine and Ionizing Irradiation [O] . T. J. Wiktor, H. G. Aaslestad, M. M. Kaplan 1972

机译：β-丙内酯乙酰基亚乙基亚胺和电离辐射灭活的狂犬病病毒的免疫原性
7. Immunogenicity of Rabies Virus Inactivated by β-Propiolactone, Acetylethyleneimine, and Ionizing Irradiation [O] . T. J. Wiktor, H. G. Aaslestad, M. M. Kaplan 1972

机译：狂犬病病毒的免疫原性由β-丙酸酯，乙酰乙基乙基亚胺和电离照射灭活

Immunogenicity of Rabies Virus Inactivated by β-Propiolactone, Acetylethyleneimine, and Ionizing Irradiation

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