Pathology of Exfoliated Oropharyngeal Epithelial Cells Infected with Wild-Type Adenovirus

David P. McCormick; Quirino Galapon; Carl Berling

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Pathology of Exfoliated Oropharyngeal Epithelial Cells Infected with Wild-Type Adenovirus

机译：野生型腺病毒感染口咽上皮脱落细胞的病理学

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Adenovirus disease was diagnosed in 2 hr by staining exfoliated infected oropharyngeal cells with fluorescein-tagged rabbit antisera to adenovirus types 4 and 7. The method was as sensitive as the standard virus isolation procedures, but serological cross reactions were observed. Viral antigens were detected in both the nucleus and cytoplasm of infected cells. Infection was accompanied by the outpouring of large numbers of polymorphonuclear leukocytes and smaller numbers of mononuclear cells. The method provides a model for the study of the cellular response to viral upper respiratory disease.

机译：通过用荧光素标记的兔抗血清对4型和7型腺病毒染色脱落的感染口咽细胞，在2小时内诊断出腺病毒疾病。该方法与标准病毒分离程序一样灵敏，但观察到血清学交叉反应。在感染细胞的细胞核和细胞质中均检测到病毒抗原。感染伴有大量多形核白细胞大量倒出和少量单核细胞倒入。该方法为研究病毒对上呼吸道疾病的细胞反应提供了模型。

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《Applied Microbiology》 |1972年第3期|共9页
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David P. McCormick; Quirino Galapon; Carl Berling;
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1. Pathology of Exfoliated Oropharyngeal Epithelial Cells Infected with Wild-Type Adenovirus [J] . David P. McCormick, Quirino Galapon, Carl Berling Applied Microbiology . 1972,第3期

机译：野生型腺病毒感染口咽上皮脱落细胞的病理学
2. Adenovirus DNA-binding protein in cells infected with wild-type 5 adenovirus and two DNA-minus, temperature-sensitive mutants, H5ts125 and H5ts149. [J] . H S Ginsberg, U Lundholm, T Linné Journal of Virology . 1977,第1期

机译：腺病毒DNA结合蛋白在感染野生型腺病毒和两个DNA-minus，温度敏感突变体，H5TS125和H5TS149的细胞中。
3. Adenovirus DNA-binding protein in cells infected with wild-type 5 adenovirus and two DNA-minus, temperature-sensitive mutants, H5ts125 and H5ts149. [J] . H S Ginsberg, U Lundholm, T Linné Journal of Virology . 1977,第1期

机译：腺病毒DNA结合蛋白在感染野生型腺病毒和两个DNA-minus，温度敏感突变体，H5TS125和H5TS149的细胞中。
4. Interaction of adenovirus with conjunctival epithelial cells as a prelude to gene therapy [C] . J.J. Yang, D. Stevenson, M. D. Trousdale, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：腺病毒与结膜上皮细胞的相互作用作为基因治疗的前奏
5. Adenovirus E1A 12S-induced changes during immortalization and transformation of primary epithelial cells. [D] . Gopalakrishnan, Shobha. 1996

机译：腺病毒E1A 12S诱导的原代上皮细胞永生化和转化过程中的变化。
6. Pathology of Exfoliated Oropharyngeal Epithelial Cells Infected with Wild-Type Adenovirus [O] . David P. McCormick, Quirino Galapon, Carl Berling 1972

机译：野生型腺病毒感染口咽上皮脱落细胞的病理学
7. Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells. [O] . Cawood, R, Chen, HH, Carroll, F, 2009

机译：使用组织特异性microRNA来控制野生型腺病毒的病理，而不会减弱其杀死癌细胞的能力。

Pathology of Exfoliated Oropharyngeal Epithelial Cells Infected with Wild-Type Adenovirus

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