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Biosynthesis of Prodigiosin, a Secondary Metabolite of Serratia marcescens

机译：Prodigiosin（粘质沙雷氏菌的次生代谢产物）的生物合成

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摘要

Prodigiosenes (prodigiosin and prodigiosin-like pigments) are known to be synthesized by only one genus of Eubacteriales and by two genera of Actinomycetales. Biosynthesis by Serratia marcescens occurs over a relatively narrow range of temperatures, although the bacteria grow over a broad range. When cultures of S. marcescens were incubated at 27 C in 1.0% casein hydrolysate, viable count and protein attained maximal values within 24 to 48 h, whereas prodigiosin did not reach a maximum until 96 h. The greatest amount of pigment was synthesized when cultures were in the senescent phase of growth. Suspensions of nonproliferating bacteria incubated at 27 C in only L-alanine also synthesized prodigiosin, although at a slower rate than growing cultures. Kinetics of growth for the wild-type, red S. marcescens and a white mutant were identical when incubated at 27 C, but the wild type produced abundant pigment. These results plus other data obtained from the literature suggest that prodigiosin is a secondary metabolite. The importance of this proposal to understanding the function of prodigiosin in S. marcescens is discussed.
机译：众所周知，dig虫（prodigiosin和类似于prodigiosin的色素）仅由一种属的真细菌和两个属的放线菌属合成。粘质沙雷氏菌的生物合成发生在相对狭窄的温度范围内，尽管细菌的生长范围很广。当马氏链球菌培养物在1.0％酪蛋白水解液中于27°C孵育时，存活数和蛋白质在24至48小时内达到最大值，而prodigiosin直到96 h才达到最大值。当培养物处于生长的衰老阶段时，合成的色素量最大。仅在L-丙氨酸中于27°C孵育的非增殖细菌悬浮液也合成了prodigiosin，尽管其速度比生长的培养物慢。在27°C孵育时，野生型红色粘菌和白色突变体的生长动力学相同，但野生型产生大量色素。这些结果以及从文献中获得的其他数据表明，prodigiosin是次生代谢产物。讨论了该建议对理解prodigiosin在粘液链球菌中的功能的重要性。

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