Biotransformation of Flurbiprofen by Cunninghamella Species

Jessica Amadio; Katherine Gordon; Cormac D. Murphy

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Biotransformation of Flurbiprofen by Cunninghamella Species

机译：坎宁哈氏菌种对氟比洛芬的生物转化

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The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and dihydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4′-hydroxyflurbiprofen was isolated by preparative high-pressure liquid chromatography (HPLC). Cunninghamella elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.

机译：在Cunninghamella spp中研究了氟化抗炎药氟比洛芬的生物转化。使用气相色谱-质谱和氟19核磁共振波谱法检测单羟基和二羟基代谢物，并通过制备高压液相色谱（HPLC）分离出主要代谢物4'-羟基氟比洛芬。秀丽线虫DSM 1908和C. blakesleeana DSM 1906也产生了II期（共轭）代谢产物，经解偶联实验鉴定为硫酸化药物。

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《Applied Microbiology》 |2010年第18期|共5页
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Jessica Amadio; Katherine Gordon; Cormac D. Murphy;
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1. Biotransformation of Flurbiprofen by Cunninghamella Species [J] . Jessica Amadio, Katherine Gordon, Cormac D. Murphy Applied and Environmental Microbiology . 2010,第18期

机译：坎宁哈氏菌种对氟比洛芬的生物转化
2. Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species [J] . Amadio Jessica, Murphy Cormac D. . Biotechnology Letters . 2011,第2期

机译：通过坎宁汉氏菌属物种的生物转化生产抗癌药物氟他胺的人类代谢产物
3. Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species [J] . Jessica Amadio, Cormac D. Murphy Biotechnology Letters . 2011,第2期

机译：通过坎宁汉氏菌属物种的生物转化生产抗癌药物氟他胺的人类代谢产物
4. Biotransformation of Artemisinin by Rhizopus chinensis and Cunninghamella elegans [C] . 北京大学中医药现代研究中心2003年年会论文集 . 2004

机译：根霉和秀丽线虫对青蒿素的生物转化
5. Azithromycin Partitioning, Biotransformation, and Bioaccumulation in Representative California River Sediment and Native Aquatic Species, Signal Crayfish (Pacifastacus leniusculus) and Rainbow Trout ( Oncorhynchus mykiss) [D] . Maier, Monica Lee Vermillion. 2018

机译：阿奇霉素在代表性的加利福尼亚河沉积物和本地水生生物，信号小龙虾（Pacifastacus leniusculus）和虹鳟（Oncorhynchus mykiss）中的分配，生物转化和生物富集
6. Biotransformation of Flurbiprofen by Cunninghamella Species [O] . Jessica Amadio, Katherine Gordon, Cormac D. Murphy 2010

机译：坎宁哈氏菌种对氟比洛芬的生物转化
7. Biotransformation of flurbiprofen by Cunninghamella species [O] . Amadio, Jessica, Gordon, Katherine, Murphy, Cormac D. 2010

机译：坎宁氏杆菌对氟比洛芬的生物转化

Biotransformation of Flurbiprofen by Cunninghamella Species

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