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首页> 外文期刊>Applied Microbiology >In Vitro Fermentation of Sugar Beet Arabino-Oligosaccharides by Fecal Microbiota Obtained from Patients with Ulcerative Colitis To Selectively Stimulate the Growth of Bifidobacterium spp. and Lactobacillus spp.
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In Vitro Fermentation of Sugar Beet Arabino-Oligosaccharides by Fecal Microbiota Obtained from Patients with Ulcerative Colitis To Selectively Stimulate the Growth of Bifidobacterium spp. and Lactobacillus spp.

机译：由溃疡性结肠炎患者获得的粪便微生物群对甜菜阿拉伯糖寡糖进行体外发酵，以选择性刺激双歧杆菌的生长。和乳杆菌属。

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The potential prebiotic properties of arabino-oligosaccharides (AOS) derived from sugar beet pulp was studied using mixed cultures of human fecal bacteria from patients with ulcerative colitis (UC), in remission or with active disease, and in healthy controls. These results were compared to those for fructo-oligosaccharides (FOS), which are known to have a prebiotic effect. Fermentation studies were carried out using a small-scale static batch system, and changes in the fecal microbial communities and metabolites were monitored after 24 h by quantitative real-time PCR and short-chain fatty acid analysis. With a few minor exceptions, AOS affected the communities similarly to what was seen for FOS. Quantitative real-time PCR revealed that Bifidobacterium spp. and Lactobacillus spp. were selectively increased after fermentation of AOS or FOS by fecal microbiota derived from UC patients. The stimulation of growth of Lactobacillus spp. and Bifidobacterium spp. was accompanied by a high production of acetate and hence a decrease of pH. The fermentation of AOS may help improve the inflammatory conditions in UC patients through stimulation of bacteria eliciting anti-inflammatory responses and through production of acetate. AOS may therefore represent a new prebiotic candidate for reduction of the risk of flare-ups in UC patients. However, human trials are needed to confirm a health-promoting effect.
机译：使用溃疡性结肠炎（UC），缓解或活动性疾病以及健康对照的人类粪便细菌的混合培养物，研究了甜菜果肉衍生的阿拉伯寡糖（AOS）的潜在益生元特性。将这些结果与已知具有益生元作用的低聚果糖（FOS）的结果进行了比较。使用小规模的静态分批系统进行发酵研究，并在24小时后通过实时定量PCR和短链脂肪酸分析监测粪便微生物群落和代谢产物的变化。除了少数例外，AOS对社区的影响与FOS一样。实时定量PCR揭示双歧杆菌属。和乳杆菌属。 UC患者的粪便菌群在AOS或FOS发酵后有选择性地增加了这些蛋白。刺激乳酸杆菌的生长。和双歧杆菌属。伴随着乙酸的高产量，因此pH降低。 AOS的发酵可通过刺激引起抗炎反应的细菌和产生乙酸盐来帮助改善UC患者的炎症状况。因此，AOS可能代表了一种新的益生元候选物，可以降低UC患者爆发发作的风险。但是，需要进行人体试验来确认促进健康的作用。

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