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首页> 外文期刊>Applied Microbiology >SlyA Regulates Type III Secretion System (T3SS) Genes in Parallel with the T3SS Master Regulator HrpL in Dickeya dadantii 3937
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SlyA Regulates Type III Secretion System (T3SS) Genes in Parallel with the T3SS Master Regulator HrpL in Dickeya dadantii 3937

机译：SlyA与Dickeya dadantii 3937中的T3SS主调节剂HrpL平行调节III型分泌系统（T3SS）基因。

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摘要

The hypersensitive response and pathogenicity ( hrp ) genes of Dickeya dadantii 3937 encode a type III secretion system (T3SS) which is essential for its full virulence. Previous studies of the T3SS regulation in D. dadantii 3937 revealed that the expression of the hrp genes is regulated by a master regulator, HrpL, through the HrpX-HrpY-HrpS-HrpL and GacS-GacA- rsmB -RsmA pathways. In this work, we identified a novel regulator of the SlyA/MarR family, SlyA, which regulates hrp genes of the HrpL regulon in parallel with HrpL in D. dadantii . SlyA regulates the T3SS in a two-tier manner. It negatively regulates the expression of hrpL by downregulating hrpS and upregulating rsmA . Interestingly, concomitant with its downregulation of the hrpL , SlyA positively regulates the expression of hrpA and hrpN , two hrp genes located in the HrpL regulon. In contrast to Pectobacterium carotovorum , the expression of slyA is not controlled by ExpR and ExpI in D. dadantii 3937. We further show that SlyA is involved in controlling swimming motility and pellicle formation in D. dadantii 3937.
机译：Dickeya dadantii 3937的超敏反应和致病性（hrp）基因编码III型分泌系统（T3SS），这对于其充分的毒力至关重要。先前对D. dadantii 3937中的T3SS调节的研究表明，hrp基因的表达是通过HrpX-HrpY-HrpS-HrpL和GacS-GacA-rsmB -RsmA途径由主调节剂HrpL调节的。在这项工作中，我们确定了SlyA / MarR家族的一种新型调节剂SlyA，它与D. dadantii中的HrpL平行调节HrpL regulon的hrp基因。 SlyA以两层方式调节T3SS。它通过下调hrpS和上调rsmA来负调控hrpL的表达。有趣的是，伴随其对hrpL的下调，SlyA正调控hrpA和hrpN的表达，hrpA和hrpN是位于hrpL调节子中的两个hrp基因。与胡萝卜杆菌相比，slyA的表达不受D. dadantii 3937中的ExpR和ExpI的控制。我们进一步证明SlyA参与控制D. dadantii 3937中的游泳运动和表皮形成。

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