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Clinical Evaluation of Kethoxal Against Cutaneous Herpes Simplex

机译：甲乙醛对皮肤单纯疱疹的临床评价

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摘要

A 2.5% preparation of kethoxal in cream was compared with the cream placebo for efficacy against cutaneous herpes simplex in a double-blind clinical study. The kethoxal formulation was not significantly more effective than the placebo. This conclusion was based on subjective impressions of the patients, observations by the physicians, and quantitative measurement of herpesvirus recovered from the lesions. It was suggested that the lack of clinical activity, in contrast to the marked activity against experimental infections in laboratory animals, resulted from the fact that high levels of herpesvirus were already present in the skin before symptoms were noted.
机译：在一项双盲临床研究中，将霜剂中2.5％的乙二醛制剂与霜剂安慰剂的抗单纯性皮肤疱疹疗效进行了比较。乙氧乙醛制剂没有比安慰剂有效得多。该结论基于患者的主观印象，医生的观察以及从病变中回收的疱疹病毒的定量测量。有人提出，与临床实验动物抗实验感染的明显活性相反，缺乏临床活性是由于在注意到症状之前皮肤中已经存在高水平的疱疹病毒。

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