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首页> 外文期刊>Applied Microbiology >Glucose Triggers ATP Secretion from Bacteria in a Growth-Phase-Dependent Manner
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Glucose Triggers ATP Secretion from Bacteria in a Growth-Phase-Dependent Manner

机译：葡萄糖以生长阶段依赖性方式触发细菌的ATP分泌

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ATP modulates immune cell functions, and ATP derived from gut commensal bacteria promotes the differentiation of T helper 17 (Th17) cells in the intestinal lamina propria. We recently reported that Enterococcus gallinarum , isolated from mice and humans, secretes ATP. We have since found and characterized several ATP-secreting bacteria. Of the tested enterococci, Enterococcus mundtii secreted the greatest amount of ATP (>2 μM/10~(8) cells) after overnight culture. Glucose, not amino acids and vitamins, was essential for ATP secretion from E. mundtii . Analyses of energy-deprived cells demonstrated that glycolysis is the most important pathway for bacterial ATP secretion. Furthermore, exponential-phase E. mundtii and Enterococcus faecalis cells secrete ATP more efficiently than stationary-phase cells. Other bacteria, including Pseudomonas aeruginosa , Escherichia coli , and Staphylococcus aureus , also secrete ATP in exponential but not stationary phase. These results suggest that various gut bacteria, including commensals and pathogens, might secrete ATP at any growth phase and modulate immune cell function.
机译：ATP调节免疫细胞功能，源自肠道共生细菌的ATP促进固有层肠T辅助17（Th17）细胞的分化。我们最近报道了从小鼠和人类分离出的鸡肠球菌分泌ATP。此后，我们发现并鉴定了几种ATP分泌细菌。培养过夜的肠球菌中，芒氏肠球菌分泌最大量的ATP（> 2μM/ 10〜（8）细胞）。葡萄糖，而不是氨基酸和维生素，对于蒙脱肠杆菌的ATP分泌至关重要。对能量缺乏的细胞的分析表明，糖酵解是细菌ATP分泌的最重要途径。此外，指数期的蒙德埃希氏菌和粪肠球菌比稳定期的细胞更有效地分泌ATP。其他细菌，包括铜绿假单胞菌，大肠埃希氏菌和金黄色葡萄球菌，也以指数形式而不是固定时期分泌ATP。这些结果表明，包括肠道菌和病原体在内的各种肠道细菌可能在任何生长期分泌ATP，并调节免疫细胞功能。

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