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首页> 外文期刊>Applied Microbiology >Association of Pandemic Vibrio parahaemolyticus O3:K6 Present in the Coastal Environment of Northwest Mexico with Cases of Recurrent Diarrhea between 2004 and 2010
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Association of Pandemic Vibrio parahaemolyticus O3:K6 Present in the Coastal Environment of Northwest Mexico with Cases of Recurrent Diarrhea between 2004 and 2010

机译：2004年至2010年间墨西哥西北海岸环境中存在的大流行性副溶血性弧菌O3：K6与反复腹泻的关系

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In 2004, more than 1,230 cases of gastroenteritis due to pandemic O3:K6 strains of Vibrio parahaemolyticus were reported in southern Sinaloa, a state in Northwestern Mexico. Recurrent sporadic cases arose from 2004 to 2010, spreading from the south to the north. In the present study, Vibrio parahaemolyticus was detected in both environmental samples and clinical cases along the Pacific coast of Sinaloa during 2004 to 2010. An evaluation was made of the serotypes, distribution of virulence genes, and presence of pandemic O3:K6 strains. A total of 144 strains were isolated from environmental samples (from sediment, seawater, and shrimp), and 154 clinical strains were isolated. A total of 10 O serogroups and 30 serovars were identified in the strains. Environmental strains ( n = 144) belonged to 10 O serogroups and 28 serovars, while clinical strains ( n = 154) belonged to 8 O serogroups and 14 serovars. Ten serovars were shared by both environmental and clinical strains. Among 144 environmental isolates, 4.1% (6/144) belonged to the pandemic clone, with 83.3% containing the orf8 gene and with O3:K6 accounting for 67%. On the other hand, pathogenic strains ( tdh and/or trh ) accounted for 52% (75/144) of the environmental isolates. Interestingly, among 154 clinical isolates, 80.5% (124/154) were pandemic strains, with O3:K6 ( tdh , toxRS _(new), and orf8 ) representing the predominant serovar (99.2%, 123/124). Overall, our results indicate that in spite of a high serodiversity and prevalence of pathogenic Vibrio parahaemolyticus in the environment, the pandemic strain O3:K6 caused >79% of reported cases between 2004 and 2010 in Sinaloa, Mexico.
机译：2004年，在墨西哥西北部的锡那罗亚州南部，报告了因副溶血性弧菌O3：K6大流行而导致的1,230例肠胃炎病例。从2004年到2010年，出现了零星的复发病例，从南部传播到北部。在本研究中，在2004年至2010年期间，在锡那罗亚州太平洋沿岸的环境样本和临床病例中均检测到副溶血性弧菌。对血清型，毒力基因分布和大流行O3：K6菌株的存在进行了评估。从环境样品（沉积物，海水和虾）中总共分离出144株菌株，并分离了154株临床菌株。在菌株中共鉴定出10 O血清群和30血清型。环境菌株（n = 144）属于10 O血清群和28个血清型，而临床菌株（n = 154）属于8 O血清群和14血清型。环境和临床菌株共有十种血清型。在144个环境分离物中，有4.1％（6/144）属于大流行性克隆，其中83.3％包含orf8基因，而O3：K6占67％。另一方面，致病菌株（tdh和/或trh）占环境分离株的52％（75/144）。有趣的是，在154种临床分离株中，有80.5％（124/154）是大流行毒株，其中O3：K6（tdh，toxRS _（new）和orf8）代表主要的血清型（99.2％，123/124）。总体而言，我们的结果表明，尽管环境中致病性副溶血性弧菌具有较高的多样性和普遍性，但在2004年至2010年之间，墨西哥锡那罗亚州的大流行毒株O3：K6导致报告病例的> 79％。

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