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首页> 外文期刊>Applied Microbiology >Population Genetic Analysis of Streptomyces albidoflavus Reveals Habitat Barriers to Homologous Recombination in the Diversification of Streptomycetes
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Population Genetic Analysis of Streptomyces albidoflavus Reveals Habitat Barriers to Homologous Recombination in the Diversification of Streptomycetes

机译：链霉菌链霉菌的种群遗传分析揭示了链霉菌多样化中的同源重组的栖息地障碍。

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Examining the population structure and the influence of recombination and ecology on microbial populations makes great sense for understanding microbial evolution and speciation. Streptomycetes are a diverse group of bacteria that are widely distributed in nature and a rich source of useful bioactive compounds; however, they are rarely subjected to population genetic investigations. In this study, we applied a five-gene-based multilocus sequence analysis (MLSA) scheme to 41 strains of Streptomyces albidoflavus derived from diverse sources, mainly insects, sea, and soil. Frequent recombination was detected in S. albidoflavus , supported by multiple lines of evidence from the pairwise homoplasy index (Φ_( w )) test, phylogenetic discordance, the Shimodaira-Hasegawa (SH) test, and network analysis, underpinning the predominance of homologous recombination within Streptomyces species. A strong habitat signal was also observed in both phylogenetic and Structure 2.3.3 analyses, indicating the importance of ecological difference in shaping the population structure. Moreover, all three habitat-associated groups, particularly the entomic group, demonstrated significantly reduced levels of gene flow with one another, generally revealing habitat barriers to recombination. Therefore, a combined effect of homologous recombination and ecology is inferred for S. albidoflavus , where dynamic evolution is at least partly balanced by the extent that differential distributions of strains among habitats limit genetic exchange. Our study stresses the significance of ecology in microbial speciation and reveals the coexistence of homologous recombination and ecological divergence in the evolution of streptomycetes.
机译：研究种群结构以及重组和生态学对微生物种群的影响对于理解微生物的进化和物种形成非常有意义。链霉菌是在自然界广泛分布的多种细菌，并且是有用生物活性化合物的丰富来源。然而，他们很少受到人口遗传调查。在这项研究中，我们对来自不同来源（主要是昆虫，海洋和土壤）的41株链霉菌链霉菌应用了基于五基因的多基因座序列分析（MLSA）方案。在成对链霉菌中检测到频繁重组，并得到了成对同源性指数（Φ_（w））测试，系统发育失调，下田长谷川（SH）测试和网络分析等多方面证据的支持，这证明了同源重组的优势在链霉菌种中。在系统发育和结构2.3.3分析中也观察到强烈的栖息地信号，表明生态差异对塑造种群结构的重要性。此外，所有三个与栖息地相关的组，尤其是昆虫学组，都显示出彼此之间基因流水平显着降低，通常揭示了重组的栖息地障碍。因此，推断出S. albidoflavus的同源重组和生态学的综合作用，其中动态进化至少部分地受到生境之间菌株差异分布限制遗传交换的程度的平衡。我们的研究强调了生态学在微生物物种形成中的重要性，并揭示了链霉菌进化过程中同源重组和生态多样性的共存。

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