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首页> 外文期刊>Applied Microbiology >Reduced Glutathione Mediates Resistance to H2S Toxicity in Oral Streptococci
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Reduced Glutathione Mediates Resistance to H2S Toxicity in Oral Streptococci

机译：减少的谷胱甘肽介导口服链球菌对H2S毒性的抵抗力

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Periodontal disease is associated with changes in the composition of the oral microflora, where health-associated oral streptococci decrease while Gram-negative anaerobes predominate in disease. A key feature of periodontal disease-associated anaerobes is their ability to produce hydrogen sulfide (H_(2)S) abundantly as a by-product of anaerobic metabolism. So far, H_(2)S has been reported to be either cytoprotective or cytotoxic by modulating bacterial antioxidant defense systems. Although oral anaerobes produce large amounts of H_(2)S, the potential effects of H_(2)S on oral streptococci are currently unknown. The aim of this study was to determine the effects of H_(2)S on the survival and biofilm formation of oral streptococci. The growth and biofilm formation of Streptococcus mitis and Streptococcus oralis were inhibited by H_(2)S. However, H_(2)S did not significantly affect the growth of Streptococcus gordonii or Streptococcus sanguinis . The differential susceptibility of oral streptococci to H_(2)S was attributed to differences in the intracellular concentrations of reduced glutathione (GSH). In the absence of GSH, H_(2)S elicited its toxicity through an iron-dependent mechanism. Collectively, our results showed that H_(2)S exerts antimicrobial effects on certain oral streptococci, potentially contributing to the decrease in health-associated plaque microflora.
机译：牙周疾病与口腔菌群组成的变化有关，健康相关的口腔链球菌减少，而革兰氏阴性厌氧菌占主导地位。牙周疾病相关厌氧菌的关键特征是它们能够大量产生硫化氢（H_（2）S）作为厌氧代谢的副产物。迄今为止，已报道通过调节细菌抗氧化剂防御系统，H_（2）S具有细胞保护性或细胞毒性。尽管口服厌氧菌会产生大量H_（2）S，但目前尚不清楚H_（2）S对口腔链球菌的潜在作用。这项研究的目的是确定H_（2）S对口腔链球菌的存活和生物膜形成的影响。 H_（2）S抑制了链球菌和口腔链球菌的生长和生物膜形成。但是，H_（2）S并没有显着影响戈登链球菌或血链球菌的生长。口服链球菌对H_（2）S的敏感性不同归因于还原型谷胱甘肽（GSH）的细胞内浓度差异。在缺乏GSH的情况下，H_（2）S通过铁依赖性机制引起其毒性。总体而言，我们的结果表明，H_（2）S对某些口服链球菌具有抗菌作用，可能有助于减少与健康相关的菌斑微生物群。

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