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首页> 外文期刊>Applied Microbiology >Genetic Basis of Tetracycline Resistance in Bifidobacterium animalis subsp. lactis
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Genetic Basis of Tetracycline Resistance in Bifidobacterium animalis subsp. lactis

机译：动物双歧杆菌亚种四环素抗性的遗传基础。乳酸菌

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All strains of Bifidobacterium animalis subsp. lactis described to date show medium level resistance to tetracycline. Screening of 26 strains from a variety of sources revealed the presence of tet (W) in all isolates. A transposase gene upstream of tet (W) was found in all strains, and both genes were cotranscribed in strain IPLAIC4. Mutants with increased tetracycline resistance as well as tetracycline-sensitive mutants of IPLAIC4 were isolated and genetically characterized. The native tet (W) gene was able to restore the resistance phenotype to a mutant with an alteration in tet (W) by functional complementation, indicating that tet (W) is necessary and sufficient for the tetracycline resistance seen in B. animalis subsp. lactis .
机译：动物双歧杆菌的所有菌株。迄今为止描述的乳酸显示对四环素的中等水平的抗性。从各种来源筛选出26个菌株，发现所有分离物中都存在tet（W）。在所有菌株中都发现了tet（W）上游的转座酶基因，并且两个基因都在IPLAIC4菌株中共转录。分离出具有增强的四环素抗性的突变体以及IPLAIC4的四环素敏感突变体并对其进行了遗传学表征。天然tet（W）基因能够通过功能互补将tet（W）发生改变的突变体恢复为抗性表型，这表明tet（W）对于动物双歧杆菌亚种中的四环素抗性是必要且充分的。乳酸菌。

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