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首页> 外文期刊>Applied Microbiology >Cooccurrence of Free-Living Amoebae and Nontuberculous Mycobacteria in Hospital Water Networks, and Preferential Growth of Mycobacterium avium in Acanthamoeba lenticulata
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Cooccurrence of Free-Living Amoebae and Nontuberculous Mycobacteria in Hospital Water Networks, and Preferential Growth of Mycobacterium avium in Acanthamoeba lenticulata

机译：医院供水网络中自由活动的变形虫和非结核分枝杆菌的同时发生，以及轻型棘金棘菌中鸟分枝杆菌的优先生长

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摘要

The incidence of lung and other diseases due to nontuberculous mycobacteria (NTM) is increasing. NTM sources include potable water, especially in households where NTM populate pipes, taps, and showerheads. NTM share habitats with free-living amoebae (FLA) and can grow in FLA as parasites or as endosymbionts. FLA containing NTM may form cysts that protect mycobacteria from disinfectants and antibiotics. We first assessed the presence of FLA and NTM in water and biofilm samples collected from a hospital, confirming the high prevalence of NTM and FLA in potable water systems, particularly in biofilms. Acanthamoeba spp. (genotype T4) were mainly recovered (8/17), followed by Hartmannella vermiformis (7/17) as well as one isolate closely related to the genus Flamella and one isolate only distantly related to previously described species. Concerning mycobacteria, Mycobacterium gordonae was the most frequently found isolate (9/17), followed by Mycobacterium peregrinum (4/17), Mycobacterium chelonae (2/17), Mycobacterium mucogenicum (1/17), and Mycobacterium avium (1/17). The propensity of Mycobacterium avium hospital isolate H87 and M. avium collection strain 104 to survive and replicate within various FLA was also evaluated, demonstrating survival of both strains in all amoebal species tested but high replication rates only in Acanthamoeba lenticulata . As A. lenticulata was frequently recovered from environmental samples, including drinking water samples, these results could have important consequences for the ecology of M. avium in drinking water networks and the epidemiology of disease due to this species.
机译：非结核分枝杆菌（NTM）引起的肺病和其他疾病的发病率正在增加。 NTM来源包括饮用水，尤其是在NTM填充管道，水龙头和淋浴喷头的家庭中。 NTM与自由活动的变形虫（FLA）共享栖息地，并且可以在FLA中作为寄生虫或共生共生体生长。含有NTM的FLA可能会形成囊肿，保护分枝杆菌免受消毒剂和抗生素的侵害。我们首先评估了从医院收集的水和生物膜样品中FLA和NTM的存在，证实了NTM和FLA在饮用水系统中，特别是在生物膜中的高流行。棘阿米巴属（T4基因型）主要被回收（8/17），其次是Vertformformis Hartmannella（7/17）以及一种与Flamella属密切相关的分离株，以及仅与上述物种远缘相关的分离株。关于分枝杆菌，戈登分枝杆菌是最常见的分离株（9/17），其次是百日咳分枝杆菌（4/17），螯合分枝杆菌（2/17），粘液分枝杆菌（1/17）和鸟分枝杆菌（1/17） ）。还评估了禽分枝杆菌医院分离株H87和鸟分枝杆菌收集菌株104在各种FLA中存活和复制的倾向，证明了这两种菌株在所有测试的变形虫中均存活，但仅在轻型棘阿米巴虫中具有高复制率。由于经常从包括饮用水样品在内的环境样品中回收轻度曲霉，因此这些结果可能会对饮用水网络中的鸟分枝杆菌的生态学以及该物种引起的疾病流行病学产生重要影响。

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