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首页> 外文期刊>Applied Microbiology >Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources
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Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

机译：从临床，环境和食物来源分离出产志贺毒素的大肠杆菌O113：H21菌株的遗传多样性和毒力潜能

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Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.
机译：O113：H21血清型的产生志贺毒素的大肠杆菌菌株已引起严重的人类疾病，但它们不常见，因为它们不产生由肠上皮细胞受损部位编码的粘附因子。在这里，PCR芯片用于表征从各个国家的环境，食物和临床感染中分离出的65种O113：H21菌株。与澳大利亚的溶血性尿毒症综合征有关的致病菌株相比，在所测试的41种遗传标记物上，病原体和环境菌株之间没有明显差异。此外，所有菌株仅携带与人类感染有关的志贺毒素亚型，这表明环境菌株具有引起疾病的潜力。大多数O113：H21菌株密切相关并属于同一克隆组（ST-223），但是CRISPR分析显示O113：H21菌株之间具有高度的遗传多样性。

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