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首页> 外文期刊>Applied Microbiology >Insights into the Metabolism of Oleaginous Rhodococcus spp.
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Insights into the Metabolism of Oleaginous Rhodococcus spp.

机译：洞悉油性红球菌属的代谢。

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Some species belonging to the Rhodococcus genus, such as Rhodococcus opacus, R. jostii, and R. wratislaviensis, are known to be oleaginous microorganisms, since they are able to accumulate triacylglycerols (TAG) at more than 20% of their weight (dry weight). Oleaginous rhodococci are promising microbial cell factories for the production of lipids to be used as fuels and chemicals. Cells could be engineered to create strains capable of producing high quantities of oils from industrial wastes and a variety of high-value lipids. The comprehensive understanding of carbon metabolism and its regulation will contribute to the design of a reliable process for bacterial oil production. Bacterial oleagenicity requires an integral configuration of metabolism and regulatory processes rather than the sole existence of an efficient lipid biosynthesis pathway. In recent years, several studies have been focused on basic aspects of TAG biosynthesis and accumulation using R. opacus PD630 and R. jostii RHA1 strains as models of oleaginous bacteria. The combination of results obtained in these studies allows us to propose a metabolic landscape for oleaginous rhodococci. In this context, this article provides a comprehensive and integrative view of different metabolic and regulatory attributes and innovations that explain the extraordinary ability of these bacteria to synthesize and accumulate TAG. We hope that the accessibility to such information in an integrated way will help researchers to rationally select new targets for further studies in the field.
机译：众所周知，属于红球菌属的某些物种，例如不透明红球菌，jostii和wratislaviensis，是油脂性微生物，因为它们能够以其重量的20％以上（干重）积累三酰甘油（TAG）。 ）。含油的杜鹃菌是有希望的微生物细胞工厂，用于生产用作燃料和化学品的脂质。可以对细胞进行改造，使其产生能够从工业废料和各种高价值脂质中产生大量油脂的菌株。对碳代谢及其调控的全面理解将有助于细菌油生产的可靠过程的设计。细菌致油性需要代谢和调节过程的整体配置，而不是仅存在有效的脂质生物合成途径。近年来，一些研究集中在使用不透明芽孢杆菌PD630和约氏假丝酵母RHA1菌株作为产油细菌模型的TAG生物合成和积累的基本方面。这些研究中获得的结果相结合，使我们能够提出油性杜鹃球菌的代谢前景。在这种情况下，本文提供了关于不同代谢和调节特性以及创新的全面综合的观点，这些特性解释了这些细菌合成和积累TAG的非凡能力。我们希望以综合的方式访问此类信息将有助于研究人员合理地选择新的目标，以便在该领域进行进一步的研究。

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