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首页> 外文期刊>Applied Microbiology >Unveiling Genomic Diversity among Members of the Species Bifidobacterium pseudolongum, a Widely Distributed Gut Commensal of the Animal Kingdom
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Unveiling Genomic Diversity among Members of the Species Bifidobacterium pseudolongum, a Widely Distributed Gut Commensal of the Animal Kingdom

机译：在物种双歧杆菌成员中揭示基因组多样性，该物种广泛分布于动物界的肠道

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摘要

Bifidobacteria are commensals of the animal gut and are commonly found in mammals, birds, and social insects. Specifically, strains of Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium longum, and Bifidobacterium pseudolongum are widely distributed in the mammalian gut. In this context, we investigated the genetic variability and metabolic abilities of the B. pseudolongum taxon, whose genomic characterization has so far not received much attention. Phylogenomic analysis of the genome sequences of 60 B. pseudolongum strains revealed that B. pseudolongum subsp. globosum and B. pseudolongum subsp. pseudolongum may actually represent two distinct bifidobacterial species. Furthermore, our analysis highlighted metabolic differences between members of these two subspecies. Moreover, comparative analyses of genetic strategies to prevent invasion of foreign DNA revealed that the B. pseudolongum subsp. globosum group exhibits greater genome plasticity. In fact, the obtained findings indicate that B. pseudolongum subsp. globosum is more adaptable to different ecological niches such as the mammalian and avian gut than is B. pseudolongum subsp. pseudolongum.IMPORTANCE Currently, little information exists on the genetics of the B. pseudolongum taxon due to the limited number of sequenced genomes belonging to this species. In order to survey genome variability within this species and explore how members of this taxon evolved as commensals of the animal gut, we isolated and decoded the genomes of 51 newly isolated strains. Comparative genomics coupled with growth profiles on different carbohydrates has further provided insights concerning the genotype and phenotype of members of the B. pseudolongum taxon.
机译：双歧杆菌是动物肠道的代名词，通常在哺乳动物，鸟类和社交昆虫中发现。具体地，青春双歧杆菌，双歧双歧杆菌，长双歧杆菌和假双歧杆菌的菌株广泛分布在哺乳动物的肠道中。在这种情况下，我们调查了假双歧杆菌分类群的遗传变异性和代谢能力，到目前为止，其基因组特征尚未引起人们的广泛关注。对60株假单胞菌菌株的基因组序列的系统学分析表明，假单胞菌是亚种。球和假双歧杆菌亚种。假long虫实际上可能代表两个不同的双歧杆菌物种。此外，我们的分析突出了这两个亚种成员之间的代谢差异。此外，对防止外来DNA入侵的遗传策略的比较分析表明，假长双歧杆菌亚种。 globosum组表现出更大的基因组可塑性。实际上，所获得的发现表明假单胞菌亚种。球孢比假单胞菌亚种更适合于不同的生态位，例如哺乳动物和禽类肠道。重要性：目前，由于属于该物种的测序基因组数量有限，因此关于假长双歧杆菌分类群的遗传学信息很少。为了调查该物种内的基因组变异性并探索该分类群的成员如何作为动物肠道的代名词，我们分离并解码了51个新分离菌株的基因组。比较基因组学与在不同碳水化合物上的生长概况相结合，进一步提供了有关假长双歧杆菌分类群成员的基因型和表型的见解。

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