• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied Microbiology >Effects of Orally Administered Bdellovibrio bacteriovorus on the Well-Being and Salmonella Colonization of Young Chicks
【24h】

Effects of Orally Administered Bdellovibrio bacteriovorus on the Well-Being and Salmonella Colonization of Young Chicks

机译：口服Bdellovibrio bacteriovorus对雏鸡的健康和沙门氏菌定殖的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bdellovibrio bacteriovorus is a bacterium which preys upon and kills Gram-negative bacteria, including the zoonotic pathogens Escherichia coli and Salmonella. Bdellovibrio has potential as a biocontrol agent, but no reports of it being tested in living animals have been published, and no data on whether Bdellovibrio might spread between animals are available. In this study, we tried to fill this knowledge gap, using B. bacteriovorus HD100 doses in poultry with a normal gut microbiota or predosed with a colonizing Salmonella strain. In both cases, Bdellovibrio was dosed orally along with antacids. After dosing non- Salmonella -infected birds with Bdellovibrio , we measured the health and well-being of the birds and any changes in their gut pathology and culturable microbiota, finding that although a Bdellovibrio dose at 2 days of age altered the overall diversity of the natural gut microbiota in 28-day-old birds, there were no adverse effects on their growth and well-being. Drinking water and fecal matter from the pens in which the birds were housed as groups showed no contamination by Bdellovibrio after dosing. Predatory Bdellovibrio orally administered to birds that had been predosed with a gut-colonizing Salmonella enterica serovar Enteritidis phage type 4 strain (an important zoonotic pathogen) significantly reduced Salmonella numbers in bird gut cecal contents and reduced abnormal cecal morphology, indicating reduced cecal inflammation, compared to the ceca of the untreated controls or a nonpredatory Δ pilA strain, suggesting that these effects were due to predatory action. This work is a first step to applying Bdellovibrio therapeutically for other animal, and possibly human, infections.
机译：Bdellovibrio bacteriovorus是捕食并杀死革兰氏阴性细菌（包括人畜共患病原体大肠杆菌和沙门氏菌）的细菌。 Bdellovibrio具有作为生物防治剂的潜力，但尚未发表有关在活体动物中对其进行测试的报道，也没有有关Bdellovibrio是否可能在动物之间传播的数据。在这项研究中，我们尝试通过在正常肠道菌群或预先接种有定殖沙门氏菌菌株的家禽中使用B. bacteriovorus HD100剂量来填补这一知识空白。在这两种情况下，Bdellovibrio都与抗酸药一起口服。在给非沙门氏菌感染的鸟类喂食Bdellovibrio后，我们测量了它们的健康状况以及它们的肠道病理学和可培养菌群的任何变化，发现尽管Bdellovibrio在2天龄时改变了其总体多样性在28天大的家禽中具有天然肠道菌群，对它们的生长和健康没有不利影响。成群饲养的钢笔中的饮用水和粪便在给药后没有显示出被Bdellovibrio污染。口服给予肠道定殖的沙门氏菌肠炎沙门氏菌肠炎沙门氏菌噬菌体4型菌株（一种重要的人畜共患病原体）的掠食性Bdellovibrio可以显着减少禽肠盲肠内容物中的沙门氏菌数量，减少异常盲肠形态，表明盲肠炎症减少对未经处理的对照或非掠食性ΔpilA菌株的盲肠中的细菌，表明这些作用是由于掠食性作用引起的。这项工作是对其他动物（可能是人类）感染进行治疗的Bdellovibrio治疗的第一步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号