Control Challenges in Synthetic Biology

Christopher V. Rao

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Control Challenges in Synthetic Biology

机译：合成生物学的控制挑战

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Automation is increasingly being employed in the life sciences. New control problems are arising as a result, few with simple off-the-shelf solutions. This paper discusses some of the scheduling and control problems associated with automation in synthetic biology. It specifically focuses on the challenges associated with robotics, drawing heavily from our own experiences at the University of Illinois at Urbana-Champaign. No solution are presented and only the problems discussed. The goal is to motivate research in the process systems engineering community to solve problems in this new field.

机译：生命科学中越来越多地采用自动化。结果出现了新的控制问题，很少有简单的现成解决方案。本文讨论了与合成生物学自动化相关的一些调度和控制问题。它主要借鉴了伊利诺伊大学香槟分校伊利诺伊大学的经验，重点关注与机器人技术相关的挑战。没有提出解决方案，仅讨论了问题。目的是激发过程系统工程界的研究人员解决这一新领域中的问题。

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《IFAC PapersOnLine》 |2015年第8期|共6页
作者
Christopher V. Rao;
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中图分类自动化技术、计算机技术;
关键词
Synthetic BiologyGenetic EngineeringControlSchedulingSupply ChainRobotics;

机译：合成生物学遗传工程控制调度供应链机器人;

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1. Controlling protein function with HCV protease Two methods for controlling protein activities with small molecules provide a general solution to a long-standing challenge in mammalian synthetic biology [J] . Dickinson Bryan C. Nature methods . 2018,第7期

机译：用HCV蛋白酶控制蛋白质功能用于控制具有小分子的蛋白质活性的方法，为哺乳动物合成生物学的长期挑战提供了一般的解决方案
2. Control Challenges in Synthetic Biology [J] . Christopher V. Rao IFAC PapersOnLine . 2015,第8期

机译：合成生物学的控制挑战
3. Synthetic Biology: A challenge to mechanical explanations in biology? [J] . MorangeM. Perspectives in Biology and Medicine . 2012,第4期

机译：合成生物学：对生物学中机械解释的挑战？
4. Challenges at the interface of control engineering and synthetic biology [C] . Harrison Steel, Gabriele Lillacci, Mustafa Khammash, IEEE Annual Conference on Decision and Control . 2017

机译：控制工程与合成生物学界面临的挑战
5. Developing Safe and Controllable Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Therapies with Design Principles of Synthetic Biology [D] . Moghadam, Farzaneh. 2020

机译：制定安全可控的集群定期间隙的短语重复（CRISPR），基于合成生物学的设计原则 - 基于设计原则的疗法
6. Managing the unimaginable. Regulatory responses to the challenges posed by synthetic biology and synthetic genomics [O] . Gabrielle N Samuel, Michael J Selgelid, Ian Kerridge 2009

机译：管理难以想象的。对合成生物学和合成基因组学带来的挑战的监管回应
7. Control Theory for Synthetic Biology: Recent Advances in System Characterization, Control Design, and Controller Implementation for Synthetic Biology [O] . Victoria Hsiao, Anandh Swaminathan, Richard M. Murray 2018

机译：合成生物学控制理论：合成生物学系统特征，控制设计和控制器实现的最新进展

Control Challenges in Synthetic Biology

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