Preparation of Cholera Vaccines by Fluorocarbon Extraction of Cholera Vibrio Suspensions

Patricia L. Altieri; Sanford Berman; Albert Groffinger; Joseph P. Lowenthal

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Preparation of Cholera Vaccines by Fluorocarbon Extraction of Cholera Vibrio Suspensions

机译：碳氟化合物提取霍乱弧菌悬液制备霍乱疫苗

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Experimental cholera vaccines were prepared from suspensions of cholera vibrios which were extracted with Genetron-113. These vaccines, when compared with a control preparation which was not treated with Genetron, had a lower nitrogen content and were less toxic for mice but were as effective in protecting mice against infection and in inducing agglutinating and vibriocidal antibody responses in rabbits. This procedure may permit the preparation of cholera vaccines with a higher antigenic content without the corresponding increase in toxic reactions.

机译：从霍乱弧菌的悬浮液制备了实验霍乱疫苗，用Genetron-113提取了霍乱弧菌。这些疫苗与未经Genetron处理的对照制剂相比，具有较低的氮含量，对小鼠的毒性较小，但在保护小鼠免受感染以及诱导兔的凝集和杀弧菌抗体反应方面同样有效。该方法可以制备具有更高抗原含量的霍乱疫苗，而不会相应增加毒性反应。

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《Infection and immunity》 |1970年第4期|共4页
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Patricia L. Altieri; Sanford Berman; Albert Groffinger; Joseph P. Lowenthal;
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中图分类医学免疫学;
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1. Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers [J] . Kamrul Islam, Motaher Hossain, Meagan Kelly, PLOS Neglected Tropical Diseases . 2018,第4期

机译：接种北美霍乱弧菌霍乱弧菌O1 El Tor Inaba的口服霍乱疫苗CVD 103-HgR疫苗接种后的抗O特异性多糖（OSP）免疫反应与霍乱防护相关
2. Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera [J] . UddinT., AktarA., XuP., The American Journal of Tropical Medicine and Hygiene . 2014,第5期

机译：口服灭活霍乱疫苗的孟加拉成年受者对霍乱弧菌O1 Ogawa的O特异性多糖和脂多糖的免疫反应及其与霍乱患者反应的比较
3. Randomized, Double-Blind, Placebo-Controlled, Multicentered Trial of the Efficacy of a Single Dose of Live Oral Cholera Vaccine CVD 103-HgR in Preventing Cholera following Challenge with Vibrio cholerae O1 El Tor Inaba Three Months after Vaccination [J] . Carol O. Tacket, Mitchell B. Cohen, Steven S. Wasserman, Infection and immunity . 1999,第12期

机译：接种霍乱弧菌O1 El Tor Inaba后三个月一次的口服活霍乱疫苗CVD 103-HgR预防霍乱的有效性，随机，双盲，安慰剂对照，多中心试验
4. Immunogenicity of live hog cholera vaccine produced by GPE- strain of hog cholera virus [C] . N. Takikawa, S. Ide, K. Saijo, Congress of the International Pig Veterinary Society . 1999

机译：GPE-猪霍乱病毒产生的活猪霍乱疫苗的免疫原性
5. Association of Cholera Toxin with Vibrio cholerae Outer Membrane Vesicles [D] . Rasti Boroujeni, Elnaz . 2020

机译：霍乱毒素与弧菌霍乱外膜囊泡的关联
6. Preparation of Cholera Vaccines by Fluorocarbon Extraction of Cholera Vibrio Suspensions [O] . Patricia L. Altieri, Sanford Berman, Albert Groffinger, 1970

机译：碳氟化合物提取霍乱弧菌悬浮液制备霍乱疫苗
7. Preparation of Cholera Vaccines by Fluorocarbon Extraction of Cholera Vibrio Suspensions [O] . Patricia L. Altieri, Sanford Berman, Albert Groffinger, 1970

机译：氟碳萃取霍乱弧菌悬浮液的霍乱疫苗的制备

Preparation of Cholera Vaccines by Fluorocarbon Extraction of Cholera Vibrio Suspensions

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