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New Classification of Neisseria meningitidis by Means of Bactericidal Reactions

机译：脑膜炎奈瑟菌的杀菌反应新分类

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A bactericidal assay is described which allows identification of distinct serotypes within a serogroup of Neisseria meningitidis. Antisera produced in rabbits against seven group C strains by two intravenous inoculations of live organisms were found to contain two types of bactericidal antibodies. One, directed against the group-specific polysaccharide, caused various degrees of killing of all strains. Absorption of this antibody by purified group C polysaccharide revealed the presence of the second bactericidal antibody. This antibody was directed against antigenically distinct factors associated with serotype specificity. Extensive cross-absorption yielded antisera with activity directed against four separate factors. The presence of a factor in a strain was indicated by its susceptibility to killing by antisera containing antibody to that factor. A serotype was defined by the particular combination of factors. Six different serotypes, containing one or two factors, were identified among 16 group C strains examined.
机译：描述了一种杀菌检测方法，可以鉴定脑膜炎奈瑟氏球菌血清群中不同的血清型。通过两次对活生物体的静脉内接种，在兔子身上产生了针对七种C组毒株的抗血清，其中含有两种杀菌抗体。一种针对群体特异性多糖，导致所有菌株的不同程度的杀死。纯化的C组多糖对该抗体的吸收揭示了第二种杀菌抗体的存在。该抗体针对与血清型特异性相关的抗原性不同因子。广泛的交叉吸收产生抗血清，其活性针对四个独立的因素。菌株中因子的存在通过其对含有针对该因子的抗体的抗血清杀死的敏感性来表明。血清型由因素的特定组合定义。在检查的16个C组菌株中鉴定出六种不同的血清型，其中包含一种或两种因子。

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