Role of Peroxide in Phagocytic Killing of Pneumococci

Jane Pitt; Harriet P. Bernheimer

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Role of Peroxide in Phagocytic Killing of Pneumococci

机译：过氧化物在肺炎球菌吞噬杀死中的作用

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Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.

机译：从亚硝基胍处理的细胞群中选择了I型肺炎球菌的两个突变体，它们的过氧化物生成减少。正常患者的白细胞杀死了突变的肺炎球菌以及其他同基因的野生型菌株。然而，在患有慢性肉芽肿性疾病的患者中，过氧化物菌株的杀死率远低于野生型。这些研究表明，除去吞噬液泡中的过氧化物生成系统会特别引起慢性肉芽肿病的杀伤缺陷。

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《Infection and immunity》 |1974年第1期|共5页
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Jane Pitt; Harriet P. Bernheimer;
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中图分类医学免疫学;
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1. Role of Peroxide in Phagocytic Killing of Pneumococci [J] . Jane Pitt, Harriet P. Bernheimer Infection and immunity . 1974,第1期

机译：过氧化物在肺炎球菌吞噬杀死中的作用
2. Lipid Peroxidation in the Killing of Phagocytized Pneumococci [J] . S. B. Shohet, J. Pitt, R. L. Baehner, Infection and immunity . 1974,第6期

机译：脂质过氧化作用在吞噬吞噬的肺炎球菌中
3. Role of the Phagocyte in Host-Parasite Interactions XI. Relationship Between Stimulated Oxidative Metabolism and Hydrogen Peroxide Formation, and Intracellular Killing [J] . R. J. McRipley, A. J. Sbarra Journal of bacteriology . 1967,第5期

机译：吞噬细胞在寄生术相互作用XI中的作用。刺激氧化代谢与过氧化氢形成的关系，细胞内杀伤
4. The Roles of Timosaponin in Inhibiting Adherence of Fungus and Enhancing Function of Phagocyte [C] . Lianlan Ma, Zhichun Liu, Xiaoyun Wu, Information technology and agricultural engineering . 2011

机译：Timosaponin在抑制真菌粘附和增强吞噬细胞功能中的作用
5. Oral Bacteria Modulate Killing of Candida albicans by Phagocytic Cells [D] . Salvatori, Ornella. 2019

机译：口腔细菌调节吞噬细胞杀害念珠菌
6. Role of Peroxide in Phagocytic Killing of Pneumococci [O] . Jane Pitt, Harriet P. Bernheimer 1974

机译：过氧化物在肺炎球菌吞噬杀死中的作用
7. KatG and KatE confer Acinetobacter resistance to hydrogen peroxide but sensitize bacteria to killing by phagocytic respiratory burst [O] . Daqing Sun, Sara A. Crowell, Christian M. Harding, 2016

机译：Katg和Kate赋予过氧化氢的抗病杆菌，但敏感细菌通过吞噬呼吸爆发杀死
8. Mechanism of Bacterial Killing by the Peritoneal and Hepatic Macrophage Population: Oxidative Bactericidal Mechanisms of Phagocytic Cells. [R] . Babior, B. M. 1976

机译：腹膜和肝巨噬细胞群细菌杀灭机制：吞噬细胞的氧化杀菌机制。

Role of Peroxide in Phagocytic Killing of Pneumococci

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