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Effect of Trace Metals on Phagocytosis by Alveolar Macrophages

机译：微量金属对肺泡巨噬细胞吞噬作用的影响

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Experiments were performed to measure the effect of trace metals on a vital function of the alveolar macrophage (AM), phagocytosis. Since certain trace metals were found to reduce the viability of AMs, a technique was developed to permit examination of live cells only for phagocytosis. Evidence is presented that Ni2+ selectively altered the phagocytic activity of AMs at concentrations lower than those which caused cell death. It is further shown that a level of VO3? that caused extensive lysis and death did not reduce phagocytosis in surviving cells. The effects of Cd2+, Cr3+, and Mn2+ on AMs were also examined.
机译：进行实验以测量痕量金属对肺泡巨噬细胞（AM）的重要功能吞噬作用的影响。由于发现某些痕量金属会降低AMs的活力，因此开发了一种技术，允许仅针对吞噬作用检查活细胞。有证据表明，Ni 2 + 有选择地改变AMs的吞噬活性，其浓度低于引起细胞死亡的浓度。进一步表明，引起广泛裂解和死亡的VO 3 ？的水平并未降低存活细胞的吞噬作用。还研究了Cd 2 + ，Cr 3 + 和Mn 2 + 对AMs的影响。

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