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首页> 外文期刊>Infection and immunity >Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States.
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Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States.

机译：Rhipicephalus sanguineus：在美国新发现的发烧人群立克次氏体的媒介。

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A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male meadow voles (Microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. It was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles afforded in 30 of 38 instances solid immunity to challenge with virulent R. rickettsii. The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells. Cytopathogenic effects were minimal unless large concentrations of rickettsiae were used as inocula. It also could be established in embryonated hen eggs but only after injection of massive doses of L cell-propagated organisms. Serological tests (complement fixation, microagglutination and/or micro immunofluorescence) indicated that the newly described Rickettsia belongs to the spotted fever group but differs from R. rickettsii, R. akari, and R. conorii. Antigenic differences were also demonstrated by direct fluorescence microscopy as well as by vaccine potency and mouse-toxin neutralization tests.
机译：在密西西比州中部和北部从狗身上摘下来的884只Rhipicephalus sanguineus中有167只（18.9％）被发现与立克次氏体立克次氏体有关，但不同于斑点发炎的立克次体。可以很容易地在雄性草地田鼠（Microtus pennsylvanicus）中分离出这种微生物，在田鼠的阴道膜组织中产生大量感染。它对雄性豚鼠几乎没有致病性，尽管在38例中的30例中，用感染的田鼠阴道真菌接种了这些动物，从而对里氏立克次氏体产生了强大的免疫力。 Rhipicephalus rickettsia在鸡胚成纤维细胞，Vero，小鼠L和HeLa细胞的单层中生长良好。除非使用大浓度的立克次体作为接种物，否则细胞致病作用是最小的。它也可以在有胚的鸡蛋中建立，但只有在注射大剂量的L细胞繁殖的生物后才能建立。血清学测试（补体固定，微凝集和/或微免疫荧光）表明，新近描述的立克次体属于斑点热组，但不同于立克次氏菌，立克次氏菌和康乃尔氏菌。通过直接荧光显微镜以及疫苗效价和小鼠毒素中和测试也证明了抗原差异。

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