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首页> 外文期刊>Infection and immunity >Hyporeactivity Due to Infection: Recognition of a Transferable Hyporeactive Factor in the Serum of Encephalomyocarditis Virus-Infected Mice
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Hyporeactivity Due to Infection: Recognition of a Transferable Hyporeactive Factor in the Serum of Encephalomyocarditis Virus-Infected Mice

机译：由于感染引起的血流动力学：脑心肌炎病毒感染的小鼠血清中可转移的血流活化因子的识别。

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As previously reported, mice infected with encephalomyocarditis (EMC) virus progressively develop a state of hyporeactivity to interferon induction as evidenced by an 80% reduction in serum interferon levels produced in response to four different inducers administered 96 h after initiation of infection. In the current report, this hyporesponsiveness was further documented in vitro in peritoneal exudate cells harvested at the time of maximal hyporeactivity (96 h) during EMC virus infection. These peritoneal cell preparations (containing no detectable interferon or virus) produced significantly less interferon than cells from uninfected mice following exposure to Newcastle disease virus or Chikungunya virus. More importantly, hyporeactivity could be transferred to normal peritoneal cells incubated in serum (containing no detectable interferon or virus) from EMC virus-infected mice during the hyporeactive period. Incubation of peritoneal exudate cells with up to a 1:200 dilution of serum from hyporeactive animals still resulted in a significant reduction in the interferon response induced by Newcastle disease virus or Chikungunya virus. Furthermore, it could be shown that this serum hyporeactive factor was effective in mouse cells but not in rabbit, chicken, or human cells.
机译：如先前报道的，感染了脑心肌炎（EMC）病毒的小鼠逐渐发展出对干扰素诱导的反应性低下的状态，这是由感染开始96小时后对四种不同的诱导剂产生的血清干扰素水平降低80％所证明的。在本报告中，这种低反应性在体外进一步证实，EMC病毒感染期间在最大反应不足（96小时）时收集的腹膜渗出液细胞中。在暴露于新城疫病毒或基孔肯雅病毒后，这些腹膜细胞制剂（不含可检测的干扰素或病毒）产生的干扰素明显少于未感染小鼠的细胞。更重要的是，低反应性可以在低反应性期间转移到来自EMC病毒感染小鼠的血清（不含可检测到的干扰素或病毒）中孵育的正常腹膜细胞中。从反应过度的动物中以最高1：200的血清稀释液腹膜渗出液的孵育仍导致新城疫病毒或基孔肯雅病毒诱导的干扰素反应显着降低。此外，可以证明该血清低反应性因子在小鼠细胞中有效，但在兔，鸡或人细胞中无效。

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