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首页> 外文期刊>Infection and immunity >Hyporeactivity to interferon induction: characterization of a hyporeactive factor in the serum of encephalomyocarditis virus-infected mice.
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Hyporeactivity to interferon induction: characterization of a hyporeactive factor in the serum of encephalomyocarditis virus-infected mice.

机译：干扰素诱导的低反应性：脑心肌炎病毒感染小鼠血清中低反应性因子的表征。

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Mice infected with encephalomyocarditis virus develop a severe state of hyporeactivity to interferon induction. One mechanisms possibly responsibile for development of hyporesponsiveness in these animals is a circulating factor which can be detected in their serum 96 h after encephalomyocarditis virus infection (at the time of peak hyporeactivity in vivo). This report describes some of the physiocochemical characteristics of this serum hyporeactive factor (SHF). SHF is a protein with a molecular weight between 20,000 and 40,000 that was extremely labile at 56 C, losing greater than 90% of its biological activity in 8 min, but stable at 37 c for at least 4 h. Hyporeactive factor was also stable over a pH range of 2 to 11 for 48 h at 4 C. These results suggest that SHF is physicochemically similar to interferon. However, no interferon could be detected in the SHF preparation, and no loss in biological activity was observed when the serum factor was incubated with anti-interferon antibody, suggesting that they are separate substances.
机译：感染了脑心肌炎病毒的小鼠对干扰素的诱导发展为严重的低反应性状态。在这些动物中可能导致低反应性发展的一种机制是循环因子，可以在脑心肌炎病毒感染后96小时（在体内出现反应不足高峰时）在其血清中检测到这种循环因子。该报告描述了该血清低反应性因子（SHF）的一些理化特性。 SHF是一种分子量在20,000至40,000之间的蛋白质，在56°C时极不稳定，在8分钟内丧失超过90％的生物活性，但在37°C下稳定至少4 h。在4 C下，在2至11的pH值范围内，Hyporeactive因子在48 h内也是稳定的。这些结果表明SHF在物理化学上类似于干扰素。然而，在SHF制剂中未检测到干扰素，并且当血清因子与抗干扰素抗体一起温育时未观察到生物学活性的损失，表明它们是分开的物质。

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