IRF family transcription factors in type I interferon induction

机译：ISF系列转录因子I型干扰素诱导

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The type I interferon (IFN-alpha/beta) gene family was identified about a quarter of century ago as the prototype of many cytokine gene families, and the gene induction mechanism for IFN-alpha/beta. was extensively studied in the context of host defense against viral infections. More recently, much attention has been focused on the induction and function of the IFN-alpha/beta system regulated by Toll-like receptors (TLRs), which are critical for linking the innate and adaptive immunities. The understanding of mechanisms underlying IFN-alpha/beta gene induction by TLRs is therefore an emerging theme, for which new insights have been gained over the past few years. We summarise recent progress on the role of interferon regulatory factors (IRFs) in the induction of IFN-alpha/beta genes in normal cells and plasmacytoid dendritic cells (pDCs) that are specialized to produce IFN-alpha/beta. at very high levels upon stimulation by TLR9 and its subfamily members.

机译：I型Interferon（IFN-alpha /β）基因家族被确定为大约四分之一世纪前作为许多细胞因子基因家族的原型，以及IFN-α/β的基因诱导机制。在对抗病毒感染的宿主防御的背景下广泛研究。最近，很多关注都集中在由Toll样受体（TLR）调节的IFN-α/β系统的诱导和功能，这对于连接先天和自适应抗扰度至关重要。因此，对TLRS的IFN-α/β基因诱导的机制理解是一个新兴主题，在过去几年中获得了新的见解。我们总结了干扰素调节因子（IRF）在诱导IFN-α/β基因的正常细胞和血浆骨质细胞树突细胞（PDC）中的作用的进展情况，该细胞（PDC）专门生产IFN-α/β。在TLR9及其亚家族成员刺激时在非常高的水平。

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《Uehara Memorial Foundation Symposium on the Innate Immune System》|2005年|1st ed|共10页
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作者
Hideyuki Yanai; Tatsuaki Mizutani; Takayuki Inuzuka; Kenya Honda; Akinori Takaoka; Tadatsugu Taniguchi;
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正文语种
中图分类免疫细胞生物学;
关键词
Interferon; IRF; Toll-like receptor 9;

机译：干扰素;IRF;Toll样受体9;

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专利

1. Type I interferon (correction of inteferon) gene induction by the interferon regulatory factor family of transcription factors. [J] . Honda K, Takaoka A, Taniguchi T Immunity . 2006,第3期

机译：I型干扰素（干扰素校正干扰素）基因诱导因转录因子家族。
2. Type I interferon system and IRF family of transcription factors in host defense regulation [J] . Tadatsugu TANIGUCHI, Akinori TAKAOKA Proceedings of the Japan Academy, Series B. Physical and Biological Sciences . 2005,第1期

机译：宿主防御调节中的I型干扰素系统和IRF转录因子家族
3. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. [J] . T Yamagata, J Nishida, S Tanaka, Molecular and Cellular Biology . 1996,第4期

机译：一种新型的干扰素调节因子家族转录因子ICSAT / Pip / LSIRF，它负面调节干扰素调节基因的活性。
4. IRF family transcription factors in type I interferon induction [C] . Hideyuki Yanai, Tatsuaki Mizutani, Takayuki Inuzuka, Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：ISF系列转录因子I型干扰素诱导
5. Molecular mechanisms by which interferon regulatory factor-8 (IRF-8), a member of the IRF family of transcription factors, suppresses tumor progression of both hematopoietic and nonhematopoietic malignancies [D] . Banik, Debarati. 2014

机译：IRF转录因子家族成员干扰素调节因子8（IRF-8）抑制造血和非造血系统恶性肿瘤的分子机制
6. Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA. [O] . S Harroch, M Revel, J Chebath 1994

机译：白细胞介素6通过回文干扰素应答元件pIRE诱导干扰素调节因子1（IRF-1）基因表达并依赖IRF-1的细胞类型依赖性控制与DNA的结合。
7. Type I Interferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors [O] . Honda Kenya, Takaoka Akinori, Taniguchi Tadatsugu 2006

机译：转录因子干扰素调节因子家族诱导I型干扰素基因

IRF family transcription factors in type I interferon induction

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