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Response of sublethally irradiated monkeys to a replicating viral antigen.

机译：次生地辐照猴子对复制病毒抗原的反应。

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摘要

Temporal effects of exposure to sublethal, total-body X radiation (400 R) on responses to vaccination with attenuated Venezuelan equine encephalomyelitis vaccine virus. TC-83, were examined in rhesus monkeys. Viremia, often with delayed onset, was prolonged even when irradiation preceded vaccination by 28 days. Virus titers were increased, articularly in groups irradiated 4 or 7 days before vaccination. Delay in appearance of hemagglutination-inhibition and serum-neutralizing antibody correlated closely with persistence of viremia in irradiated-vaccinated monkeys. The temporal course of antibody response was markedly affected by the intervals between irradiation and injection of this replicating antigen. With longer intervals between irradiation and vaccination, the somewhat depressed antibody responses approached normal or surpassed those of nonirradiated monkeys. Vaccination 14 days after radiation exposure resulted in lethality to 8 of 12 monkeys, apparently as a result of secondary infection. The additional lymphopenic stress due to the effect of TC-83, superimposed on the severly depressed hematopoietic competence at 14 days, undoubtedly contributed to this increased susceptibility to latent infection.
机译：暴露于亚致死剂量的全身X射线辐射（400 R）对减毒的委内瑞拉马脑脊髓炎疫苗病毒疫苗接种反应的时间影响。在恒河猴中检查了TC-83。病毒血症（通常具有延迟发作）即使在放疗前先接种疫苗28天也能延长。在接种疫苗前4或7天进行辐照的组中，特别是在各组中，病毒滴度有所增加。血凝抑制和血清中和抗体的出现延迟与经辐射接种的猴子的病毒血症持续时间密切相关。抗体反应的时间过程受辐照和注射此复制性抗原之间的时间间隔显着影响。在辐照和疫苗接种之间间隔更长的时间，稍微降低的抗体应答接近正常或超过未辐照猴子的应答。辐射暴露后14天进行疫苗接种会导致12只猴子中的8只死亡，这显然是继发感染的结果。由于TC-83的作用，附加的淋巴细胞减少应激叠加在14天时严重降低的造血能力上，无疑助长了这种潜在感染的易感性。

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