Experimental herpes simplex virus carditis in mice.

E I Grodums; A Zbitnew

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Experimental herpes simplex virus carditis in mice.

机译：小鼠实验性单纯疱疹病毒性心脏病。

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Herpes simplex virus types 1 and 2 induced acute and chronic cardiac damage in suckling and weaning mice after intranasal inoculation. Signs of virus replication were detected by light, immunofluorescent, and electron microscopy techniques. Virtually all of the cardiac tissues appeared to be susceptible to herpes simplex virus. The myocardium, however, was most regularly affected. The viral lesions were discrete during the acute phase of infection. The cardiac damage, however, was more extensive in some of the chronically infected mice. Morphologically, these lesions either resembled the acute ones or were associated with inflammatory granulomatous and sclerotic changes.

机译：鼻内接种后，1型和2型单纯疱疹病毒在乳鼠和断奶小鼠中引起急性和慢性心脏损伤。通过光，免疫荧光和电子显微镜技术检测到病毒复制的迹象。几乎所有心脏组织似乎都对单纯疱疹病毒敏感。然而，心肌最经常受到影响。在感染的急性期，病毒性病变是离散的。但是，在一些慢性感染的小鼠中，心脏损害更为广泛。从形态上讲，这些病变要么类似于急性病变，要么与炎性肉芽肿和硬化性变化有关。

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《Infection and immunity》 |1976年第6期|共10页
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E I Grodums; A Zbitnew;
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中图分类医学免疫学;
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6. Experimental herpes simplex virus carditis in mice. [O] . E I Grodums, A Zbitnew 1976

机译：小鼠实验性单纯疱疹病毒性心脏病。
7. Activity of AMP against experimental herpes simplex virus type 1 infections in mice. [O] . Blue, W T, Macias, E A, Sklar, S H 1983

机译：AMP对小鼠实验性单纯疱疹病毒1型感染的活性。

Experimental herpes simplex virus carditis in mice.

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