Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.

Haas J; Meyding Lamade-U; Fath A; Stingele K; Storch Hagenlocher-B; Wildemann B

首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.

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Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.

机译：阿昔洛韦治疗实验性单纯疱疹病毒性脑炎的方法：监测SJL小鼠脑组织中免疫NO合酶表达和病毒载量的变化。

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The effect of acyclovir treatment on viral burden and the expression of immunologic nitric oxide synthase (iNOS) within brains of 42 HSV-1 F infected mice was studied by using a titration PCR assay for HSV-1 DNA and a semiquantitative RT-PCR for iNOS mRNA. iNOS mediated NO-production may possibly be involved in secondary mechanisms of brain injury following virus infection, which may account for treatment failures in human herpes simplex virus encephalitis (HSVE). Following infection, a parallel increase of iNOS mRNA and HSV-1F-DNA occurred with peaks after 7 days that were both significantly lower under acyclovir treatment. Six months post infection viral load had declined, but iNOS mRNA expression in both treated and untreated mice was still enhanced as compared with mock infected controls. This suggests that acyclovir decreases iNOS expression via inhibition of viral replication shortly after infection but fails to influence elevated iNOS within the brain late in the course of experimental HSVE.

机译：使用滴定PCR检测HSV-1 DNA和半定量RT-PCR研究无环鸟苷治疗对42例HSV-1 F感染小鼠的病毒载量和免疫性一氧化氮合酶（iNOS）表达的影响mRNA。 iNOS介导的NO产生可能与病毒感染后脑损伤的继发机制有关，这可能是人类单纯疱疹病毒性脑炎（HSVE）治疗失败的原因。感染后，iNOS mRNA和HSV-1F-DNA平行增加，并在7天后出现峰值，在阿昔洛韦治疗下均明显降低。感染后六个月病毒载量下降，但与模拟感染的对照组相比，治疗和未治疗小鼠中iNOS mRNA的表达仍得到增强。这表明阿昔洛韦在感染后不久就通过抑制病毒复制而降低了iNOS的表达，但在实验性HSVE过程的后期却无法影响脑内升高的iNOS。

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《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 |1999年第3期|共4页
作者
Haas J; Meyding Lamade-U; Fath A; Stingele K; Storch Hagenlocher-B; Wildemann B;
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正文语种 eng
中图分类人体生理学;
关键词
Acyclovir; Antiviral Agents; Encephalitis; Herpes Simplex; Nitric-Oxide Synthase; 阿昔洛韦; 抗病毒药; 脑炎; 疱疹; 单纯; 一氧化氮合酶;

机译：Acyclovir;Antiviral Agents;Encephalitis;Herpes Simplex;Nitric-Oxide Synthase;阿昔洛韦;抗病毒药;脑炎;疱疹;单纯;一氧化氮合酶;

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1. Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice. [J] . Haas J, Meyding Lamade-U, Fath A, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1999,第1a3期

机译：阿昔洛韦治疗实验性单纯疱疹病毒性脑炎的方法：监测SJL小鼠脑组织中免疫NO合酶表达和病毒载量的变化。
2. Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue. [J] . Meyding-Lamade U, Haas J, Lamade W, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1998,第1期

机译：单纯疱疹病毒性脑炎：小鼠脑组织中病毒载量和免疫性一氧化氮合酶表达的长期比较研究。
3. Experimental herpes simplex virus encephalitis: inhibition of the expression of inducible nitric oxide synthase in mouse brain tissue. [J] . Meyding-Lamade Uta, Seyfer Sonja, Haas Jurgen, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2002,第1期

机译：实验性单纯疱疹病毒性脑炎：抑制小鼠脑组织中诱导型一氧化氮合酶的表达。
4. Amino Acid Substitutions in the Thymidine Kinase Gene of Induced Acyclovir-Resistant Herpes Simplex Virus Type 1 [C] . Ainulkhir Hussin, Norefrina Shafinaz Md Nor, Nazlina Ibrahim UKM FST Postgraduate Colloquium . 2013

机译：诱导诱导的Acyclovir耐药疱疹病毒型肾小序激酶基因的氨基酸取代1
5. A critical role and a critical period for herpes simplex virus-specific CD8+ T lymphocyte infiltration into the central nervous system: Impact on the development of stress-induced herpes simplex encephalitis. [D] . Anglen, Crystal S. 2003

机译：单纯疱疹病毒特异性CD8 + T淋巴细胞浸入中枢神经系统的关键作用和关键时期：对应激诱导的单纯疱疹性脑炎发展的影响。
6. Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice. [O] . H Machida, M Ichikawa, A Kuninaka, 1980

机译：1-β-D-阿拉伯呋喃糖基胸腺嘧啶对小鼠单纯性疱疹病毒诱发的实验性脑炎的治疗作用。
7. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis [O] . Debra C. Quenelle, Alexander Birkmann, Thomas Goldner, 2018

机译：Pritelivir和Acyclovir在单纯疱疹脑膜炎疱疹模型中治疗单纯疱疹病毒感染治疗疱疹病毒感染的疗效
8. Amplification of Herpes Simplex Virus Types 1 and 2 and Human Herpes Virus Type 5 Polymerase Gene Segment From Formalin-Fixed Brain Tissue From Alzheimer's Disease Patients [R] . Henrichs, L. E. 2005

机译：从阿尔茨海默病患者的福尔马林固定脑组织扩增1型和2型单纯疱疹病毒和人类疱疹病毒5型聚合酶基因片段

Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.

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