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首页> 外文期刊>Infection and immunity >Immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans.
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Immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans.

机译：核糖体疫苗与细菌细胞壁佐剂相关的免疫刺激。

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We have studied a new vaccine of ribosomal nature associated with glycoprotein cell walls from Klebsiella pneumoniae which served as an immunoadjuvant. Thus vaccine was administered by the aerosol route to working men free of any important disease, especially of respiratory disease. A total of 104 men working for the Commissariat à l'Energie Atomique, all volunteers, were randomly placed into two groups. During the first period, 51 patients (group I) were vaccinated three times a week during 5 weeks, and the second group was used as control. During the second period, which started on day 225, the control group received the vaccine, and the first group was revaccinated. Results of this experience show a significant difference in the immunity of the two groups. The specific antibodies increased with vaccination as illustrated by chi-square test (Yates correction), which corresponds to an independent probability equal to 0 (P = 0.5 X 10-4).
机译：我们已经研究了一种新的具有核糖体性质的疫苗，该疫苗与肺炎克雷伯菌的糖蛋白细胞壁有关，可作为免疫佐剂。因此，疫苗是通过气雾途径向没有任何重要疾病，特别是呼吸系统疾病的劳动者施用的。共有104名为能源委员会工作的男性志愿者被随机分为两组。在第一个阶段中，有51名患者（I组）在5周内每周接种3次疫苗，第二组作为对照组。在从225天开始的第二个阶段中，对照组接受了疫苗接种，第一组进行了疫苗接种。这项经验的结果表明两组的免疫力有显着差异。如卡方检验（Yates校正）所示，特异性抗体随疫苗接种而增加，这对应于等于0的独立概率（P = 0.5 X 10-4）。

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