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首页> 外文期刊>Infection and immunity >A Chromosomal Locus Which Controls the Ability of Shigella flexneri to Evoke Keratoconjunctivitis
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A Chromosomal Locus Which Controls the Ability of Shigella flexneri to Evoke Keratoconjunctivitis

机译：控制弗氏志贺氏菌诱发角膜结膜炎能力的染色体位点

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The primary step in the pathogenesis of bacillary dysentery is the penetration of intestinal epithelial cells by shigellae. Lacking this capacity, Shigella flexneri becomes avirulent. By means of intergeneric conjugation between various Escherichia coli K-12 Hfr strains and S. flexneri 2a virulent recipients and by reciprocal transduction analysis with phage P1 vir, we established a locus on the genome of S. flexneri 2a which is necessary for the ability of this strain to penetrate epithelial cells as measured by the Sereney test for keratoconjunctivitis. This locus, termed kcpA (in reference to its involvement in provoking keratoconjunctivitis), has been positioned between the lac and gal chromosomal markers and is contransducible with the purE allele.
机译：细菌性痢疾发病机理的第一步是志贺氏菌对肠道上皮细胞的渗透。缺乏这种能力，弗氏志贺氏菌变得无毒。通过多种大肠杆菌 K-12 Hfr菌株与 S的种间共轭。 flexneri 2a毒力受体，并通过噬菌体P1 vir 的互导分析，在 S基因组上建立了一个基因座。 flexeri 2a，这对于该菌株穿透角膜结膜炎的Sereney试验所测量的穿透上皮细胞的能力是必需的。称为 kcpA 的基因座（指其参与引起角膜结膜炎），已位于 lac 和 gal 染色体标记之间，并且可转导 purE 等位基因。

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